A saturation-mutagenesis analysis of the interplay between stability and activation in Ras

Cancer mutations in Ras occur predominantly at three hotspots: Gly 12, Gly 13, and Gln 61. Previously, we reported that deep mutagenesis of H-Ras using a bacterial assay identified many other activating mutations (Bandaru et al., 2017). We now show that the results of saturation mutagenesis of H-Ras...

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Detalles Bibliográficos
Autores principales: Hidalgo, Frank, Nocka, Laura M, Shah, Neel H, Gorday, Kent, Latorraca, Naomi R, Bandaru, Pradeep, Templeton, Sage, Lee, David, Karandur, Deepti, Pelton, Jeffrey G, Marqusee, Susan, Wemmer, David, Kuriyan, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916776/
https://www.ncbi.nlm.nih.gov/pubmed/35272765
http://dx.doi.org/10.7554/eLife.76595

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