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No Histological Difference between Large Atherosclerotic and Cardiogenic Embolic Thrombus
BACKGROUND: The continuous development of endovascular treatment technology provides more opportunities for the histological study of thrombus. According to Trial of Org 10 172 in Acute Stroke Treatment (TOAST), clinicians take different strategies in anticoagulant or antiplatelet therapy. There are...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916853/ https://www.ncbi.nlm.nih.gov/pubmed/35281464 http://dx.doi.org/10.1155/2022/4845264 |
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author | Chen, Rui Zeng, Xiaopeng Liu, Yong Huang, Cheng Yang, Jun |
author_facet | Chen, Rui Zeng, Xiaopeng Liu, Yong Huang, Cheng Yang, Jun |
author_sort | Chen, Rui |
collection | PubMed |
description | BACKGROUND: The continuous development of endovascular treatment technology provides more opportunities for the histological study of thrombus. According to Trial of Org 10 172 in Acute Stroke Treatment (TOAST), clinicians take different strategies in anticoagulant or antiplatelet therapy. There are some patients still suffering from recurrent stroke while they took anticoagulant or antiplatelet drugs regularly for secondary prevention. In view of that, we found that histological analysis of thrombus can provide guidance for secondary prevention. AIM: Exploring the histological characteristics differences between large atherosclerotic and cardiogenic embolic thrombosis in order to guide clinical secondary prevention of the two stroke subtypes. METHODS: A total of 54 patients with acute ischemic stroke were collected from December 2019 to April 2021. Identify stroke subtypes according to TOAST classification. Stain thrombus specimens with hematoxylin-eosin staining, and perform statistical analysis on the components (red blood cells and fibrin/platelets) of thrombus. RESULTS: In cardiogenic thrombi, the composition of RBCs was dominant (51.38 ± 18.463%) compared to that of fibrin/platelets (48.62 ± 18.463%). Similarly, among the thrombi of large artery atherosclerotic, RBCs (50.40 ± 20.100%) compared to fibrin/platelets (49.60 ± 20.100%). There was no statistical difference in RBCs or fibrin/platelet composition of both cardiogenic and atherosclerotic thrombi (P = 0.89). CONCLUSIONS: The histologic composition of thrombi in cardiogenic and atherosclerotic had no statistical difference. These thrombi are all mixed thrombus, which are rich in RBCs, fibrinogen, and platelets. Anticoagulation combined with antiplatelet may be a more effective secondary prevention strategy. |
format | Online Article Text |
id | pubmed-8916853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-89168532022-03-12 No Histological Difference between Large Atherosclerotic and Cardiogenic Embolic Thrombus Chen, Rui Zeng, Xiaopeng Liu, Yong Huang, Cheng Yang, Jun Oxid Med Cell Longev Research Article BACKGROUND: The continuous development of endovascular treatment technology provides more opportunities for the histological study of thrombus. According to Trial of Org 10 172 in Acute Stroke Treatment (TOAST), clinicians take different strategies in anticoagulant or antiplatelet therapy. There are some patients still suffering from recurrent stroke while they took anticoagulant or antiplatelet drugs regularly for secondary prevention. In view of that, we found that histological analysis of thrombus can provide guidance for secondary prevention. AIM: Exploring the histological characteristics differences between large atherosclerotic and cardiogenic embolic thrombosis in order to guide clinical secondary prevention of the two stroke subtypes. METHODS: A total of 54 patients with acute ischemic stroke were collected from December 2019 to April 2021. Identify stroke subtypes according to TOAST classification. Stain thrombus specimens with hematoxylin-eosin staining, and perform statistical analysis on the components (red blood cells and fibrin/platelets) of thrombus. RESULTS: In cardiogenic thrombi, the composition of RBCs was dominant (51.38 ± 18.463%) compared to that of fibrin/platelets (48.62 ± 18.463%). Similarly, among the thrombi of large artery atherosclerotic, RBCs (50.40 ± 20.100%) compared to fibrin/platelets (49.60 ± 20.100%). There was no statistical difference in RBCs or fibrin/platelet composition of both cardiogenic and atherosclerotic thrombi (P = 0.89). CONCLUSIONS: The histologic composition of thrombi in cardiogenic and atherosclerotic had no statistical difference. These thrombi are all mixed thrombus, which are rich in RBCs, fibrinogen, and platelets. Anticoagulation combined with antiplatelet may be a more effective secondary prevention strategy. Hindawi 2022-03-04 /pmc/articles/PMC8916853/ /pubmed/35281464 http://dx.doi.org/10.1155/2022/4845264 Text en Copyright © 2022 Rui Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Chen, Rui Zeng, Xiaopeng Liu, Yong Huang, Cheng Yang, Jun No Histological Difference between Large Atherosclerotic and Cardiogenic Embolic Thrombus |
title | No Histological Difference between Large Atherosclerotic and Cardiogenic Embolic Thrombus |
title_full | No Histological Difference between Large Atherosclerotic and Cardiogenic Embolic Thrombus |
title_fullStr | No Histological Difference between Large Atherosclerotic and Cardiogenic Embolic Thrombus |
title_full_unstemmed | No Histological Difference between Large Atherosclerotic and Cardiogenic Embolic Thrombus |
title_short | No Histological Difference between Large Atherosclerotic and Cardiogenic Embolic Thrombus |
title_sort | no histological difference between large atherosclerotic and cardiogenic embolic thrombus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916853/ https://www.ncbi.nlm.nih.gov/pubmed/35281464 http://dx.doi.org/10.1155/2022/4845264 |
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