Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children

OBJECTIVE: To investigate the role and mechanism of lncRNA-pvt1 in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). METHODS: The expression of lncRNA-pvt1 in bone marrow tissues of ALL patients after initial diagnosis and complete remission was detected by RT-PCR to explore its poss...

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Detalles Bibliográficos
Autores principales: Cheng, Yanli, Hao, Guoping, Wang, Xiaohuan, Lu, Haiyan, Wang, Jing, Suo, Taoli, Hou, Zhaohui, Guo, Huimin, Zhang, Shixun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916858/
https://www.ncbi.nlm.nih.gov/pubmed/35281949
http://dx.doi.org/10.1155/2022/8955322
Descripción
Sumario:OBJECTIVE: To investigate the role and mechanism of lncRNA-pvt1 in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). METHODS: The expression of lncRNA-pvt1 in bone marrow tissues of ALL patients after initial diagnosis and complete remission was detected by RT-PCR to explore its possible involvement in the pathogenesis of ALL. The proliferation and apoptosis of Jurkat cells transfected with lncRNA-pvt1 were observed by MTT and flow cytometry. RESULTS: lncRNA-pvt1 expression was upregulated in bone marrow of ALL patients. Knockdown of lncRNA-pvt1 inhibited Jurkat cell proliferation and increased its apoptosis rate. CONCLUSION: Silencing lncRNA-pvt1 expression can inhibit the development of ALL.

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