Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children

OBJECTIVE: To investigate the role and mechanism of lncRNA-pvt1 in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). METHODS: The expression of lncRNA-pvt1 in bone marrow tissues of ALL patients after initial diagnosis and complete remission was detected by RT-PCR to explore its poss...

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Autores principales: Cheng, Yanli, Hao, Guoping, Wang, Xiaohuan, Lu, Haiyan, Wang, Jing, Suo, Taoli, Hou, Zhaohui, Guo, Huimin, Zhang, Shixun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916858/
https://www.ncbi.nlm.nih.gov/pubmed/35281949
http://dx.doi.org/10.1155/2022/8955322
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author Cheng, Yanli
Hao, Guoping
Wang, Xiaohuan
Lu, Haiyan
Wang, Jing
Suo, Taoli
Hou, Zhaohui
Guo, Huimin
Zhang, Shixun
author_facet Cheng, Yanli
Hao, Guoping
Wang, Xiaohuan
Lu, Haiyan
Wang, Jing
Suo, Taoli
Hou, Zhaohui
Guo, Huimin
Zhang, Shixun
author_sort Cheng, Yanli
collection PubMed
description OBJECTIVE: To investigate the role and mechanism of lncRNA-pvt1 in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). METHODS: The expression of lncRNA-pvt1 in bone marrow tissues of ALL patients after initial diagnosis and complete remission was detected by RT-PCR to explore its possible involvement in the pathogenesis of ALL. The proliferation and apoptosis of Jurkat cells transfected with lncRNA-pvt1 were observed by MTT and flow cytometry. RESULTS: lncRNA-pvt1 expression was upregulated in bone marrow of ALL patients. Knockdown of lncRNA-pvt1 inhibited Jurkat cell proliferation and increased its apoptosis rate. CONCLUSION: Silencing lncRNA-pvt1 expression can inhibit the development of ALL.
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spelling pubmed-89168582022-03-12 Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children Cheng, Yanli Hao, Guoping Wang, Xiaohuan Lu, Haiyan Wang, Jing Suo, Taoli Hou, Zhaohui Guo, Huimin Zhang, Shixun Comput Math Methods Med Research Article OBJECTIVE: To investigate the role and mechanism of lncRNA-pvt1 in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). METHODS: The expression of lncRNA-pvt1 in bone marrow tissues of ALL patients after initial diagnosis and complete remission was detected by RT-PCR to explore its possible involvement in the pathogenesis of ALL. The proliferation and apoptosis of Jurkat cells transfected with lncRNA-pvt1 were observed by MTT and flow cytometry. RESULTS: lncRNA-pvt1 expression was upregulated in bone marrow of ALL patients. Knockdown of lncRNA-pvt1 inhibited Jurkat cell proliferation and increased its apoptosis rate. CONCLUSION: Silencing lncRNA-pvt1 expression can inhibit the development of ALL. Hindawi 2022-03-04 /pmc/articles/PMC8916858/ /pubmed/35281949 http://dx.doi.org/10.1155/2022/8955322 Text en Copyright © 2022 Yanli Cheng et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cheng, Yanli
Hao, Guoping
Wang, Xiaohuan
Lu, Haiyan
Wang, Jing
Suo, Taoli
Hou, Zhaohui
Guo, Huimin
Zhang, Shixun
Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children
title Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children
title_full Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children
title_fullStr Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children
title_full_unstemmed Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children
title_short Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children
title_sort role and mechanism of lncrna-pvt1 in the pathogenesis of acute lymphoblastic leukemia in children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916858/
https://www.ncbi.nlm.nih.gov/pubmed/35281949
http://dx.doi.org/10.1155/2022/8955322
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