Impact of Antibodies Against Polyethylene Glycol on the Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukaemia: A Population Pharmacokinetic Approach

BACKGROUND AND OBJECTIVES: Besides allergic reactions, antibodies against polyethylene glycol (PEG) have been associated with reduced PEG-asparaginase (PEG-ASNase) activity. Population pharmacokinetics (popPK) allow for an in-depth investigation of the influence of anti-PEG antibodies on PEG-ASNase...

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Detalles Bibliográficos
Autores principales: Siebel, Christian, Lanvers-Kaminsky, Claudia, Alten, Julia, Smisek, Petr, Nath, Christa E., Rizzari, Carmelo, Boos, Joachim, Würthwein, Gudrun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917038/
https://www.ncbi.nlm.nih.gov/pubmed/34878584
http://dx.doi.org/10.1007/s13318-021-00741-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917038/
https://www.ncbi.nlm.nih.gov/pubmed/34878584
http://dx.doi.org/10.1007/s13318-021-00741-w

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