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Impact of Antibodies Against Polyethylene Glycol on the Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukaemia: A Population Pharmacokinetic Approach

BACKGROUND AND OBJECTIVES: Besides allergic reactions, antibodies against polyethylene glycol (PEG) have been associated with reduced PEG-asparaginase (PEG-ASNase) activity. Population pharmacokinetics (popPK) allow for an in-depth investigation of the influence of anti-PEG antibodies on PEG-ASNase...

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Detalles Bibliográficos
Autores principales:	Siebel, Christian, Lanvers-Kaminsky, Claudia, Alten, Julia, Smisek, Petr, Nath, Christa E., Rizzari, Carmelo, Boos, Joachim, Würthwein, Gudrun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917038/ https://www.ncbi.nlm.nih.gov/pubmed/34878584 http://dx.doi.org/10.1007/s13318-021-00741-w

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