Platelets differentially modulate CD4(+) Treg activation via GPIIa/IIIb-, fibrinogen-, and PAR4-dependent pathways

CD4(+)FoxP3(+) regulatory T cells (CD4(+) Tregs) are known to dampen inflammation following severe trauma. Platelets were shown to augment their posttraumatic activation in burn injury, but the exact mechanisms remain unclear. We hypothesized that platelet activation mechanisms via GPIIb/IIIa, fibri...

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Detalles Bibliográficos
Autores principales: Bock, Matthias, Bergmann, Christian B., Jung, Sonja, Biberthaler, Peter, Heimann, Laura, Hanschen, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917040/
https://www.ncbi.nlm.nih.gov/pubmed/34932195
http://dx.doi.org/10.1007/s12026-021-09258-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917040/
https://www.ncbi.nlm.nih.gov/pubmed/34932195
http://dx.doi.org/10.1007/s12026-021-09258-5

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