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Disparate effects of ankle-brachial index on mortality in the ‘very old’ and ‘younger old’ populations-the PolSenior survey
To assess the relationship between ankle-brachial index (ABI) and up to 10-year mortality in older individuals below and above the age of 80 years. In a multicenter survey of health status in the community dwelling subjects aged 55–59 and 65 + years in Poland, we assessed baseline medical history in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Japan
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917102/ https://www.ncbi.nlm.nih.gov/pubmed/34643792 http://dx.doi.org/10.1007/s00380-021-01949-1 |
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author | Królczyk, Jarosław Skalska, Anna Piotrowicz, Karolina Mossakowska, Małgorzata Grodzicki, Tomasz Gąsowski, Jerzy |
author_facet | Królczyk, Jarosław Skalska, Anna Piotrowicz, Karolina Mossakowska, Małgorzata Grodzicki, Tomasz Gąsowski, Jerzy |
author_sort | Królczyk, Jarosław |
collection | PubMed |
description | To assess the relationship between ankle-brachial index (ABI) and up to 10-year mortality in older individuals below and above the age of 80 years. In a multicenter survey of health status in the community dwelling subjects aged 55–59 and 65 + years in Poland, we assessed baseline medical history including risk-factors. We measured ABI, and serum creatinine, cholesterol, NT-proBNP, and interleukin-6 (IL-6) concentrations. We assessed mortality based on public registry. Between 2009 and 2019, 27.3% of 561 participants < 80 years, and 79.4% of 291 participants ≥ 80 years, died (p < 0.001); 67.8, 41.5, and 40.3% in the ABI groups < 0.9, 0.9–1.4, and > 1.4, respectively (p < 0.01). In the unadjusted Cox models, ABI was associated with mortality in the entire group, and < 80 years. In the entire group, analysis adjusted for age and sex showed mortality risk increased by 11% per year, and 50% with male sex. Mortality decreased by 37% per 1 unit ABI increase. In the group of people ≥ 80 years, only age was significantly associated with mortality (p < 0.001). In stepwise regression ABI < 0.9, male sex, active smoking, and NT-proBNP level were associated with risk of death < 80 years. In the ≥ 80 years old, mortality risk was associated with older age, and higher levels of IL-6, but not ABI. The ABI < 0.9 is associated with higher mortality in older people, but not among the oldest-old. In the oldest age group, age is the strongest predictor of death. In this age group, inflammageing is of importance. |
format | Online Article Text |
id | pubmed-8917102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-89171022022-03-17 Disparate effects of ankle-brachial index on mortality in the ‘very old’ and ‘younger old’ populations-the PolSenior survey Królczyk, Jarosław Skalska, Anna Piotrowicz, Karolina Mossakowska, Małgorzata Grodzicki, Tomasz Gąsowski, Jerzy Heart Vessels Original Article To assess the relationship between ankle-brachial index (ABI) and up to 10-year mortality in older individuals below and above the age of 80 years. In a multicenter survey of health status in the community dwelling subjects aged 55–59 and 65 + years in Poland, we assessed baseline medical history including risk-factors. We measured ABI, and serum creatinine, cholesterol, NT-proBNP, and interleukin-6 (IL-6) concentrations. We assessed mortality based on public registry. Between 2009 and 2019, 27.3% of 561 participants < 80 years, and 79.4% of 291 participants ≥ 80 years, died (p < 0.001); 67.8, 41.5, and 40.3% in the ABI groups < 0.9, 0.9–1.4, and > 1.4, respectively (p < 0.01). In the unadjusted Cox models, ABI was associated with mortality in the entire group, and < 80 years. In the entire group, analysis adjusted for age and sex showed mortality risk increased by 11% per year, and 50% with male sex. Mortality decreased by 37% per 1 unit ABI increase. In the group of people ≥ 80 years, only age was significantly associated with mortality (p < 0.001). In stepwise regression ABI < 0.9, male sex, active smoking, and NT-proBNP level were associated with risk of death < 80 years. In the ≥ 80 years old, mortality risk was associated with older age, and higher levels of IL-6, but not ABI. The ABI < 0.9 is associated with higher mortality in older people, but not among the oldest-old. In the oldest age group, age is the strongest predictor of death. In this age group, inflammageing is of importance. Springer Japan 2021-10-13 2022 /pmc/articles/PMC8917102/ /pubmed/34643792 http://dx.doi.org/10.1007/s00380-021-01949-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Królczyk, Jarosław Skalska, Anna Piotrowicz, Karolina Mossakowska, Małgorzata Grodzicki, Tomasz Gąsowski, Jerzy Disparate effects of ankle-brachial index on mortality in the ‘very old’ and ‘younger old’ populations-the PolSenior survey |
title | Disparate effects of ankle-brachial index on mortality in the ‘very old’ and ‘younger old’ populations-the PolSenior survey |
title_full | Disparate effects of ankle-brachial index on mortality in the ‘very old’ and ‘younger old’ populations-the PolSenior survey |
title_fullStr | Disparate effects of ankle-brachial index on mortality in the ‘very old’ and ‘younger old’ populations-the PolSenior survey |
title_full_unstemmed | Disparate effects of ankle-brachial index on mortality in the ‘very old’ and ‘younger old’ populations-the PolSenior survey |
title_short | Disparate effects of ankle-brachial index on mortality in the ‘very old’ and ‘younger old’ populations-the PolSenior survey |
title_sort | disparate effects of ankle-brachial index on mortality in the ‘very old’ and ‘younger old’ populations-the polsenior survey |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917102/ https://www.ncbi.nlm.nih.gov/pubmed/34643792 http://dx.doi.org/10.1007/s00380-021-01949-1 |
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