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Super-enhancers and novel therapeutic targets in colorectal cancer

Transcription factors, cofactors, chromatin regulators, and transcription apparatuses interact with transcriptional regulatory elements, including promoters, enhancers, and super-enhancers (SEs), to coordinately regulate the transcription of target genes and thereby control cell behaviors. Among the...

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Autores principales: Liu, Qian, Guo, Lijuan, Lou, Zhiyuan, Xiang, Xueping, Shao, Jimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917125/
https://www.ncbi.nlm.nih.gov/pubmed/35277481
http://dx.doi.org/10.1038/s41419-022-04673-4
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author Liu, Qian
Guo, Lijuan
Lou, Zhiyuan
Xiang, Xueping
Shao, Jimin
author_facet Liu, Qian
Guo, Lijuan
Lou, Zhiyuan
Xiang, Xueping
Shao, Jimin
author_sort Liu, Qian
collection PubMed
description Transcription factors, cofactors, chromatin regulators, and transcription apparatuses interact with transcriptional regulatory elements, including promoters, enhancers, and super-enhancers (SEs), to coordinately regulate the transcription of target genes and thereby control cell behaviors. Among these transcriptional regulatory components and related elements, SEs often play a central role in determining cell identity and tumor initiation and progression. Therefore, oncogenic SEs, which are generated within cancer cells in oncogenes and other genes important in tumor pathogenesis, have emerged as attractive targets for novel cancer therapeutic strategies in recent years. Herein, we review the identification, formation and activation modes, and regulatory mechanisms for downstream genes and pathways of oncogenic SEs. We also review the therapeutic strategies and compounds targeting oncogenic SEs in colorectal cancer and other malignancies.
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spelling pubmed-89171252022-03-25 Super-enhancers and novel therapeutic targets in colorectal cancer Liu, Qian Guo, Lijuan Lou, Zhiyuan Xiang, Xueping Shao, Jimin Cell Death Dis Review Article Transcription factors, cofactors, chromatin regulators, and transcription apparatuses interact with transcriptional regulatory elements, including promoters, enhancers, and super-enhancers (SEs), to coordinately regulate the transcription of target genes and thereby control cell behaviors. Among these transcriptional regulatory components and related elements, SEs often play a central role in determining cell identity and tumor initiation and progression. Therefore, oncogenic SEs, which are generated within cancer cells in oncogenes and other genes important in tumor pathogenesis, have emerged as attractive targets for novel cancer therapeutic strategies in recent years. Herein, we review the identification, formation and activation modes, and regulatory mechanisms for downstream genes and pathways of oncogenic SEs. We also review the therapeutic strategies and compounds targeting oncogenic SEs in colorectal cancer and other malignancies. Nature Publishing Group UK 2022-03-11 /pmc/articles/PMC8917125/ /pubmed/35277481 http://dx.doi.org/10.1038/s41419-022-04673-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Liu, Qian
Guo, Lijuan
Lou, Zhiyuan
Xiang, Xueping
Shao, Jimin
Super-enhancers and novel therapeutic targets in colorectal cancer
title Super-enhancers and novel therapeutic targets in colorectal cancer
title_full Super-enhancers and novel therapeutic targets in colorectal cancer
title_fullStr Super-enhancers and novel therapeutic targets in colorectal cancer
title_full_unstemmed Super-enhancers and novel therapeutic targets in colorectal cancer
title_short Super-enhancers and novel therapeutic targets in colorectal cancer
title_sort super-enhancers and novel therapeutic targets in colorectal cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917125/
https://www.ncbi.nlm.nih.gov/pubmed/35277481
http://dx.doi.org/10.1038/s41419-022-04673-4
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