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Structural basis for modulation of human Na(V)1.3 by clinical drug and selective antagonist

Voltage-gated sodium (Na(V)) channels play fundamental roles in initiating and propagating action potentials. Na(V)1.3 is involved in numerous physiological processes including neuronal development, hormone secretion and pain perception. Here we report structures of human Na(V)1.3/β1/β2 in complex w...

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Detalles Bibliográficos
Autores principales:	Li, Xiaojing, Xu, Feng, Xu, Hao, Zhang, Shuli, Gao, Yiwei, Zhang, Hongwei, Dong, Yanli, Zheng, Yanchun, Yang, Bei, Sun, Jianyuan, Zhang, Xuejun Cai, Zhao, Yan, Jiang, Daohua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917200/ https://www.ncbi.nlm.nih.gov/pubmed/35277491 http://dx.doi.org/10.1038/s41467-022-28808-5

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