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Understanding the functional role of membrane confinements in TNF-mediated signaling by multiscale simulations
The interaction between TNFα and TNFR1 is essential in maintaining tissue development and immune responses. While TNFR1 is a cell surface receptor, TNFα exists in both soluble and membrane-bound forms. Interestingly, it was found that the activation of TNFR1-mediated signaling pathways is preferenti...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917213/ https://www.ncbi.nlm.nih.gov/pubmed/35277586 http://dx.doi.org/10.1038/s42003-022-03179-1 |