Synthesis, α-glucosidase inhibition, α-amylase inhibition, and molecular docking studies of 3,3-di(indolyl)indolin-2-ones

The synthesized 3,3-di(indolyl)indolin-2-ones 1a-p showed desired higher α-glucosidase inhibitory activities and lower α-amylase inhibitory activities than standard drug acarbose. Particularly, compound 1i showed favorable higher α-glucosidase % inhibition of 67 ± 13 and lower α-amylase % inhibition...

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Detalles Bibliográficos
Autores principales: Santoso, Mardi, Ong, Li Lin, Aijijiyah, Nur Pasca, Wati, First Ambar, Azminah, Azminah, Annuur, Rose Malina, Fadlan, Arif, Judeh, Zaher M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917276/
https://www.ncbi.nlm.nih.gov/pubmed/35287328
http://dx.doi.org/10.1016/j.heliyon.2022.e09045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917276/
https://www.ncbi.nlm.nih.gov/pubmed/35287328
http://dx.doi.org/10.1016/j.heliyon.2022.e09045

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