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Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins

The human apolipoprotein E4 isoform (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), and lysosomal dysfunction has been implicated in AD pathogenesis. We found, by examining cells stably expressing each APOE isoform, that APOE4 increases lysosomal traffickin...

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Detalles Bibliográficos
Autores principales:	Fote, Gianna M., Geller, Nicolette R., Efstathiou, Nikolaos E., Hendricks, Nathan, Vavvas, Demetrios G., Reidling, Jack C., Thompson, Leslie M., Steffan, Joan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917355/ https://www.ncbi.nlm.nih.gov/pubmed/34982109 http://dx.doi.org/10.1242/jcs.258687

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