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Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide

Identifying inhibitors of pathogenic proteins is the major strategy of targeted drug discoveries. This strategy meets challenges in targeting neurodegenerative disorders such as Huntington’s disease (HD), which is mainly caused by the mutant huntingtin protein (mHTT), an “undruggable” pathogenic pro...

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Detalles Bibliográficos
Autores principales:	Song, Haikun, Wang, Cen, Zhu, Chenggang, Wang, Ziying, Yang, Huiya, Wu, Peng, Cui, Xiaotian, Botas, Juan, Dang, Yongjun, Ding, Yu, Fei, Yiyan, Lu, Boxun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917382/ https://www.ncbi.nlm.nih.gov/pubmed/35238684 http://dx.doi.org/10.1073/pnas.2114303119

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