Drug metabolic activity is a critical cell-intrinsic determinant for selection of hepatocytes during long-term culture

BACKGROUND: The liver plays an important role in various metabolic processes, including protein synthesis, lipid and drug metabolisms and detoxifications. Primary culture of hepatocytes is used for the understanding of liver physiology as well as for the drug development. Hepatocytes are, however, h...

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Detalles Bibliográficos
Autores principales: Akiyama, Saeko, Saku, Noriaki, Miyata, Shoko, Ite, Kenta, Toyoda, Masashi, Kimura, Tohru, Kuroda, Masahiko, Nakazawa, Atsuko, Kasahara, Mureo, Nonaka, Hidenori, Kamiya, Akihide, Kiyono, Tohru, Kobayshi, Tohru, Murakami, Yasufumi, Umezawa, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917760/
https://www.ncbi.nlm.nih.gov/pubmed/35279203
http://dx.doi.org/10.1186/s13287-022-02776-5

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