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High PPT1 expression predicts poor clinical outcome and PPT1 inhibitor DC661 enhances sorafenib sensitivity in hepatocellular carcinoma

BACKGROUND: Adaptive resistance and side effects of sorafenib treatment result in unsatisfied survival of patients with hepatocellular carcinoma (HCC). Palmitoyl-protein thioesterase 1 (PPT1) plays a critical role in progression of various cancers. However, its role on prognosis and immune infiltrat...

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Detalles Bibliográficos
Autores principales:	Xu, Jianjun, Su, Zhe, Cheng, Xiang, Hu, Shaobo, Wang, Wenjie, Zou, Tianhao, Zhou, Xing, Song, Zifang, Xia, Yun, Gao, Yang, Zheng, Qichang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917761/ https://www.ncbi.nlm.nih.gov/pubmed/35277179 http://dx.doi.org/10.1186/s12935-022-02508-y

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