Cargando…

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19

In the past 2 years, the coronavirus disease 2019 (COVID-19) pandemic has driven investigational studies and controlled clinical trials on antiviral treatments and vaccines that have undergone regulatory approval. Now that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its vari...

Descripción completa

Detalles Bibliográficos
Autores principales: Fazio, Serafino, Affuso, Flora, Bellavite, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917781/
https://www.ncbi.nlm.nih.gov/pubmed/35256581
http://dx.doi.org/10.12659/MSM.936292
_version_ 1784668621360857088
author Fazio, Serafino
Affuso, Flora
Bellavite, Paolo
author_facet Fazio, Serafino
Affuso, Flora
Bellavite, Paolo
author_sort Fazio, Serafino
collection PubMed
description In the past 2 years, the coronavirus disease 2019 (COVID-19) pandemic has driven investigational studies and controlled clinical trials on antiviral treatments and vaccines that have undergone regulatory approval. Now that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants may become endemic over time, there remains a need to identify drugs that treat the symptoms of COVID-19 and prevent progression toward severe cases, hospitalization, and death. Understanding the molecular mechanisms of SARS-CoV-2 infection is extremely important for the development of effective therapies against COVID-19. This review outlines the key pathways involved in the host response to SARS-CoV-2 infection and discusses the potential role of antioxidant and anti-inflammatory pharmacological approaches for the management of early mild-to-moderate COVID-19, using the examples of combined indomethacin, low-dose aspirin, omeprazole, hesperidin, quercetin, and vitamin C. The pharmacological targets of these substances are described here for their possible synergism in counteracting SARS-CoV-2 replication and progression of the infection from the upper respiratory airways to the blood, avoiding vascular complications and cytokine and bradykinin storms.
format Online
Article
Text
id pubmed-8917781
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher International Scientific Literature, Inc.
record_format MEDLINE/PubMed
spelling pubmed-89177812022-03-29 A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19 Fazio, Serafino Affuso, Flora Bellavite, Paolo Med Sci Monit Review Articles In the past 2 years, the coronavirus disease 2019 (COVID-19) pandemic has driven investigational studies and controlled clinical trials on antiviral treatments and vaccines that have undergone regulatory approval. Now that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants may become endemic over time, there remains a need to identify drugs that treat the symptoms of COVID-19 and prevent progression toward severe cases, hospitalization, and death. Understanding the molecular mechanisms of SARS-CoV-2 infection is extremely important for the development of effective therapies against COVID-19. This review outlines the key pathways involved in the host response to SARS-CoV-2 infection and discusses the potential role of antioxidant and anti-inflammatory pharmacological approaches for the management of early mild-to-moderate COVID-19, using the examples of combined indomethacin, low-dose aspirin, omeprazole, hesperidin, quercetin, and vitamin C. The pharmacological targets of these substances are described here for their possible synergism in counteracting SARS-CoV-2 replication and progression of the infection from the upper respiratory airways to the blood, avoiding vascular complications and cytokine and bradykinin storms. International Scientific Literature, Inc. 2022-03-08 /pmc/articles/PMC8917781/ /pubmed/35256581 http://dx.doi.org/10.12659/MSM.936292 Text en © Med Sci Monit, 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Review Articles
Fazio, Serafino
Affuso, Flora
Bellavite, Paolo
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19
title A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19
title_full A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19
title_fullStr A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19
title_full_unstemmed A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19
title_short A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19
title_sort review of the potential roles of antioxidant and anti-inflammatory pharmacological approaches for the management of mild-to-moderate symptomatic covid-19
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917781/
https://www.ncbi.nlm.nih.gov/pubmed/35256581
http://dx.doi.org/10.12659/MSM.936292
work_keys_str_mv AT fazioserafino areviewofthepotentialrolesofantioxidantandantiinflammatorypharmacologicalapproachesforthemanagementofmildtomoderatesymptomaticcovid19
AT affusoflora areviewofthepotentialrolesofantioxidantandantiinflammatorypharmacologicalapproachesforthemanagementofmildtomoderatesymptomaticcovid19
AT bellavitepaolo areviewofthepotentialrolesofantioxidantandantiinflammatorypharmacologicalapproachesforthemanagementofmildtomoderatesymptomaticcovid19
AT fazioserafino reviewofthepotentialrolesofantioxidantandantiinflammatorypharmacologicalapproachesforthemanagementofmildtomoderatesymptomaticcovid19
AT affusoflora reviewofthepotentialrolesofantioxidantandantiinflammatorypharmacologicalapproachesforthemanagementofmildtomoderatesymptomaticcovid19
AT bellavitepaolo reviewofthepotentialrolesofantioxidantandantiinflammatorypharmacologicalapproachesforthemanagementofmildtomoderatesymptomaticcovid19