Metformin synergistically increases the anticancer effects of lapatinib through induction of apoptosis and modulation of Akt/AMPK pathway in SK-BR3 breast cancer cell line

OBJECTIVE(S): Combination chemotherapy is a beneficial intervention for breast cancer, versus single therapy. We investigated the effect of Metformin (Met) on Lapatinib (Lap)-induced apoptosis in SK-BR3 cells. MATERIALS AND METHODS: Toxic effect of Met and Lap on SK-BR3 cells was measured using MTT...

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Detalles Bibliográficos
Autores principales: Neamati, Davood, Khedri, Azam, Aberomand, Mohammad, Hemmati, Ali-Asghar, Mohammadzadeh, Maryam, Akbari Baghbani, Kourosh, Mohammadzadeh, Ghorban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917838/
https://www.ncbi.nlm.nih.gov/pubmed/35317106
http://dx.doi.org/10.22038/IJBMS.2021.58825.13069

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