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Multiple sclerosis and genetic polymorphisms in fibrinogen-mediated hemostatic pathways: a case–control study
INTRODUCTION: Blood coagulation constituents might exert immunomodulatory functions in the CNS and may trigger neuroinflammation and demyelination. We evaluated whether particular single-nucleotide polymorphisms (SNPs), thought to be involved in fibrinogen-mediated hemostatic pathways, are overrepre...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918146/ https://www.ncbi.nlm.nih.gov/pubmed/34561786 http://dx.doi.org/10.1007/s10072-021-05608-1 |
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author | Abbadessa, Gianmarco Miele, Giuseppina Di Pietro, Andrea Sparaco, Maddalena Palladino, Raffaele Armetta, Ignazio D’Elia, Giovanna Trojsi, Francesca Signoriello, Elisabetta Lus, Giacomo Lavorgna, Luigi Bonavita, Simona |
author_facet | Abbadessa, Gianmarco Miele, Giuseppina Di Pietro, Andrea Sparaco, Maddalena Palladino, Raffaele Armetta, Ignazio D’Elia, Giovanna Trojsi, Francesca Signoriello, Elisabetta Lus, Giacomo Lavorgna, Luigi Bonavita, Simona |
author_sort | Abbadessa, Gianmarco |
collection | PubMed |
description | INTRODUCTION: Blood coagulation constituents might exert immunomodulatory functions in the CNS and may trigger neuroinflammation and demyelination. We evaluated whether particular single-nucleotide polymorphisms (SNPs), thought to be involved in fibrinogen-mediated hemostatic pathways, are overrepresented in patients with MS compared with controls. METHODS: The case–control study consisted of 119 MS patients recruited consecutively at our clinic, and 68 healthy controls. Afterwards, we created a cumulative genetic risk score (CGRS) which included the 5 selected hemostatic risk alleles (Beta-Fibrinogen 455G/A, Glycoprotein IIIa P1A2, Factor V Leiden, Factor V H2R, and Prothrombin 20210G/A). Multivariate ordinal logistic regression and multivariate multinomial logistic regression were applied to evaluate the effect of CGRS on MS susceptibility. RESULTS: The FGB 455 G/A and Factor V H1299R variants might be associated with MS status, in the recessive and dominant model, respectively. A cumulative association of the five SNPs investigated with the disease was observed. DISCUSSION: We found that MS patients carried more pro-hemostatic variants than healthy controls. An increasing number of unfavorable alleles might increase the likelihood of being in the MS group, in the cumulative analysis. Our findings encourage to evaluating these variants in a larger population-based cohort. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10072-021-05608-1. |
format | Online Article Text |
id | pubmed-8918146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-89181462022-03-17 Multiple sclerosis and genetic polymorphisms in fibrinogen-mediated hemostatic pathways: a case–control study Abbadessa, Gianmarco Miele, Giuseppina Di Pietro, Andrea Sparaco, Maddalena Palladino, Raffaele Armetta, Ignazio D’Elia, Giovanna Trojsi, Francesca Signoriello, Elisabetta Lus, Giacomo Lavorgna, Luigi Bonavita, Simona Neurol Sci Original Article INTRODUCTION: Blood coagulation constituents might exert immunomodulatory functions in the CNS and may trigger neuroinflammation and demyelination. We evaluated whether particular single-nucleotide polymorphisms (SNPs), thought to be involved in fibrinogen-mediated hemostatic pathways, are overrepresented in patients with MS compared with controls. METHODS: The case–control study consisted of 119 MS patients recruited consecutively at our clinic, and 68 healthy controls. Afterwards, we created a cumulative genetic risk score (CGRS) which included the 5 selected hemostatic risk alleles (Beta-Fibrinogen 455G/A, Glycoprotein IIIa P1A2, Factor V Leiden, Factor V H2R, and Prothrombin 20210G/A). Multivariate ordinal logistic regression and multivariate multinomial logistic regression were applied to evaluate the effect of CGRS on MS susceptibility. RESULTS: The FGB 455 G/A and Factor V H1299R variants might be associated with MS status, in the recessive and dominant model, respectively. A cumulative association of the five SNPs investigated with the disease was observed. DISCUSSION: We found that MS patients carried more pro-hemostatic variants than healthy controls. An increasing number of unfavorable alleles might increase the likelihood of being in the MS group, in the cumulative analysis. Our findings encourage to evaluating these variants in a larger population-based cohort. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10072-021-05608-1. Springer International Publishing 2021-09-24 2022 /pmc/articles/PMC8918146/ /pubmed/34561786 http://dx.doi.org/10.1007/s10072-021-05608-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Abbadessa, Gianmarco Miele, Giuseppina Di Pietro, Andrea Sparaco, Maddalena Palladino, Raffaele Armetta, Ignazio D’Elia, Giovanna Trojsi, Francesca Signoriello, Elisabetta Lus, Giacomo Lavorgna, Luigi Bonavita, Simona Multiple sclerosis and genetic polymorphisms in fibrinogen-mediated hemostatic pathways: a case–control study |
title | Multiple sclerosis and genetic polymorphisms in fibrinogen-mediated hemostatic pathways: a case–control study |
title_full | Multiple sclerosis and genetic polymorphisms in fibrinogen-mediated hemostatic pathways: a case–control study |
title_fullStr | Multiple sclerosis and genetic polymorphisms in fibrinogen-mediated hemostatic pathways: a case–control study |
title_full_unstemmed | Multiple sclerosis and genetic polymorphisms in fibrinogen-mediated hemostatic pathways: a case–control study |
title_short | Multiple sclerosis and genetic polymorphisms in fibrinogen-mediated hemostatic pathways: a case–control study |
title_sort | multiple sclerosis and genetic polymorphisms in fibrinogen-mediated hemostatic pathways: a case–control study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918146/ https://www.ncbi.nlm.nih.gov/pubmed/34561786 http://dx.doi.org/10.1007/s10072-021-05608-1 |
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