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Early Changes and Predictive Value of Serum Histone H3 Concentration in Urosepsis: A Prospective Observational Study
INTRODUCTION: To assess early changes in serum histone H3 concentration in patients with urosepsis and its predictive ability for the onset of urosepsis. METHODS: A total of 80 patients who underwent percutaneous nephrolithotripsy were enrolled in the study and divided into control and urosepsis gro...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918176/ https://www.ncbi.nlm.nih.gov/pubmed/35066799 http://dx.doi.org/10.1007/s12325-021-02026-9 |
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author | Zhan, Xiangcheng Liu, Ding Dong, Yunze Gao, Yunchen Xu, Xiao Xie, Tiancheng Zhou, Hongmin Wang, Guangchun Zhang, Haimin Wu, Pengfei He, Xulin Sun, Chao Yao, Xudong Xu, Yunfei |
author_facet | Zhan, Xiangcheng Liu, Ding Dong, Yunze Gao, Yunchen Xu, Xiao Xie, Tiancheng Zhou, Hongmin Wang, Guangchun Zhang, Haimin Wu, Pengfei He, Xulin Sun, Chao Yao, Xudong Xu, Yunfei |
author_sort | Zhan, Xiangcheng |
collection | PubMed |
description | INTRODUCTION: To assess early changes in serum histone H3 concentration in patients with urosepsis and its predictive ability for the onset of urosepsis. METHODS: A total of 80 patients who underwent percutaneous nephrolithotripsy were enrolled in the study and divided into control and urosepsis groups based on their postoperative outcomes. Serum histone H3 concentrations were detected using an enzyme-linked immunosorbent assay, blood indexes were tested by automatic blood analyzers, and vital signs data were obtained by monitors and manual measurements. These results were correlated with the incidence of postoperative urosepsis. Repeated measurements and receiver operating characteristic curves were employed to analyze early changes and the predictive value of serum histone H3 concentration in urosepsis. RESULTS: Sixteen of the 80 patients (20%) developed urosepsis after surgery. Our data showed significant intra-group differences in terms of postoperative histone H3 concentrations (P < 0.0001) and variation trends (P < 0.0001). Among analyzed blood markers, serum histone H3 concentrations 3 h postoperation [0.825 (95% confidence interval 0.718–0.931, P < 0.0001; cut-off value 256.74 ng/ml, 93.8% sensitivity, 67.2% specificity)] and 6 h post-operation [0.834 (95% CI 0.721–0.947, P < 0.0001, cut-off value 300.875 ng/ml, 68.8% sensitivity, 87.5% specificity)] displayed a higher area under the corresponding receiver operating characteristic curves, indicating that these markers had a decent predictive value for postoperative urosepsis. CONCLUSION: Our study suggests that serum histone H3 concentration is a novel predictor of postoperative urosepsis in patients undergoing percutaneous nephrolithotripsy. The findings of this study can be validated in a larger cohort. CLINICAL TRIAL REGISTRY NUMBER: ChiCTR1800016679. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12325-021-02026-9. |
format | Online Article Text |
id | pubmed-8918176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-89181762022-03-17 Early Changes and Predictive Value of Serum Histone H3 Concentration in Urosepsis: A Prospective Observational Study Zhan, Xiangcheng Liu, Ding Dong, Yunze Gao, Yunchen Xu, Xiao Xie, Tiancheng Zhou, Hongmin Wang, Guangchun Zhang, Haimin Wu, Pengfei He, Xulin Sun, Chao Yao, Xudong Xu, Yunfei Adv Ther Original Research INTRODUCTION: To assess early changes in serum histone H3 concentration in patients with urosepsis and its predictive ability for the onset of urosepsis. METHODS: A total of 80 patients who underwent percutaneous nephrolithotripsy were enrolled in the study and divided into control and urosepsis groups based on their postoperative outcomes. Serum histone H3 concentrations were detected using an enzyme-linked immunosorbent assay, blood indexes were tested by automatic blood analyzers, and vital signs data were obtained by monitors and manual measurements. These results were correlated with the incidence of postoperative urosepsis. Repeated measurements and receiver operating characteristic curves were employed to analyze early changes and the predictive value of serum histone H3 concentration in urosepsis. RESULTS: Sixteen of the 80 patients (20%) developed urosepsis after surgery. Our data showed significant intra-group differences in terms of postoperative histone H3 concentrations (P < 0.0001) and variation trends (P < 0.0001). Among analyzed blood markers, serum histone H3 concentrations 3 h postoperation [0.825 (95% confidence interval 0.718–0.931, P < 0.0001; cut-off value 256.74 ng/ml, 93.8% sensitivity, 67.2% specificity)] and 6 h post-operation [0.834 (95% CI 0.721–0.947, P < 0.0001, cut-off value 300.875 ng/ml, 68.8% sensitivity, 87.5% specificity)] displayed a higher area under the corresponding receiver operating characteristic curves, indicating that these markers had a decent predictive value for postoperative urosepsis. CONCLUSION: Our study suggests that serum histone H3 concentration is a novel predictor of postoperative urosepsis in patients undergoing percutaneous nephrolithotripsy. The findings of this study can be validated in a larger cohort. CLINICAL TRIAL REGISTRY NUMBER: ChiCTR1800016679. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12325-021-02026-9. Springer Healthcare 2022-01-23 2022 /pmc/articles/PMC8918176/ /pubmed/35066799 http://dx.doi.org/10.1007/s12325-021-02026-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Zhan, Xiangcheng Liu, Ding Dong, Yunze Gao, Yunchen Xu, Xiao Xie, Tiancheng Zhou, Hongmin Wang, Guangchun Zhang, Haimin Wu, Pengfei He, Xulin Sun, Chao Yao, Xudong Xu, Yunfei Early Changes and Predictive Value of Serum Histone H3 Concentration in Urosepsis: A Prospective Observational Study |
title | Early Changes and Predictive Value of Serum Histone H3 Concentration in Urosepsis: A Prospective Observational Study |
title_full | Early Changes and Predictive Value of Serum Histone H3 Concentration in Urosepsis: A Prospective Observational Study |
title_fullStr | Early Changes and Predictive Value of Serum Histone H3 Concentration in Urosepsis: A Prospective Observational Study |
title_full_unstemmed | Early Changes and Predictive Value of Serum Histone H3 Concentration in Urosepsis: A Prospective Observational Study |
title_short | Early Changes and Predictive Value of Serum Histone H3 Concentration in Urosepsis: A Prospective Observational Study |
title_sort | early changes and predictive value of serum histone h3 concentration in urosepsis: a prospective observational study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918176/ https://www.ncbi.nlm.nih.gov/pubmed/35066799 http://dx.doi.org/10.1007/s12325-021-02026-9 |
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