Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts

OBJECTIVE: Type 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In previous work, we investigated the genetic basis of this heterogeneity by clustering 94 T2D genetic loci using their associations with 47 diabetes-related traits and identified five clusters, termed...

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Detalles Bibliográficos
Autores principales: DiCorpo, Daniel, LeClair, Jessica, Cole, Joanne B., Sarnowski, Chloé, Ahmadizar, Fariba, Bielak, Lawrence F., Blokstra, Anneke, Bottinger, Erwin P., Chaker, Layal, Chen, Yii-Der I., Chen, Ye, de Vries, Paul S., Faquih, Tariq, Ghanbari, Mohsen, Gudmundsdottir, Valborg, Guo, Xiuqing, Hasbani, Natalie R., Ibi, Dorina, Ikram, M. Arfan, Kavousi, Maryam, Leonard, Hampton L., Leong, Aaron, Mercader, Josep M., Morrison, Alanna C., Nadkarni, Girish N., Nalls, Mike A., Noordam, Raymond, Preuss, Michael, Smith, Jennifer A., Trompet, Stella, Vissink, Petra, Yao, Jie, Zhao, Wei, Boerwinkle, Eric, Goodarzi, Mark O., Gudnason, Vilmundur, Jukema, J. Wouter, Kardia, Sharon L.R., Loos, Ruth J.F., Liu, Ching-Ti, Manning, Alisa K., Mook-Kanamori, Dennis, Pankow, James S., Picavet, H. Susan J., Sattar, Naveed, Simonsick, Eleanor M., Verschuren, W.M. Monique, Willems van Dijk, Ko, Florez, Jose C., Rotter, Jerome I., Meigs, James B., Dupuis, Josée, Udler, Miriam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2022
Materias:
Pathophysiology/Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918228/
https://www.ncbi.nlm.nih.gov/pubmed/35085396
http://dx.doi.org/10.2337/dc21-1395

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