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12-month survival in nonagenarians inside the Mugello study: on the way to live a century
BACKGROUND: Life expectancy has increased over the last century and a growing number of people is reaching age 90 years and over. However, data on nonagenarians’ health trends are scarce due to difficulties in investigating this specific population. This study aims to identify risk factors for one-y...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918304/ https://www.ncbi.nlm.nih.gov/pubmed/35279074 http://dx.doi.org/10.1186/s12877-022-02908-9 |
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author | Pancani, Silvia Lombardi, Gemma Sofi, Francesco Gori, Anna Maria Boni, Roberta Castagnoli, Chiara Paperini, Anita Pasquini, Guido Vannetti, Federica Lova, Raffaello Molino Macchi, Claudio Cecchi, Francesca |
author_facet | Pancani, Silvia Lombardi, Gemma Sofi, Francesco Gori, Anna Maria Boni, Roberta Castagnoli, Chiara Paperini, Anita Pasquini, Guido Vannetti, Federica Lova, Raffaello Molino Macchi, Claudio Cecchi, Francesca |
author_sort | Pancani, Silvia |
collection | PubMed |
description | BACKGROUND: Life expectancy has increased over the last century and a growing number of people is reaching age 90 years and over. However, data on nonagenarians’ health trends are scarce due to difficulties in investigating this specific population. This study aims to identify risk factors for one-year mortality in nonagenarians using data collected within the “Mugello Study”. METHODS: Complete information on sociodemographic data, cognitive and functional status, lifestyle, medical history, and drug use was collected from 433 nonagenarians, as well as information about survival after 1 year from the interview. RESULTS: The sample included 314 women (72.5%) and 119 men (27.5%) with a median age of 92 years (range 90-99 years). The mortality rate was 20.3% (88 deaths). After adjustment for age and sex, a significantly higher risk of dying within 12 months was observed in individuals with more severe cognitive impairment (HR = 5.011, p < 0.001), more severe disability in basic activities of daily living (HR = 4.193, p < 0.001), sedentary lifestyle (HR = 3.367, p < 0.001), higher number of drugs assumed (HR = 1.118, p = 0.031), and kidney dysfunction (HR = 2.609, p = 0.004). When all the variables were included in the analysis, only older age (HR = 1.079, p = 0.048), lower cognitive function (HR = 2.859, p = 0.015), sedentary lifestyle (HR = 2.030, p = 0.026), and kidney dysfunction (HR = 2.322, p = 0.018) remained significantly associated with reduced survival. CONCLUSIONS: Data from the Mugello study support the hypothesis that survival at 12 months in nonagenarians is not a stochastic process and that older age, reduced cognitive function, sedentary lifestyle, and the presence of kidney dysfunction are associated with mortality. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-022-02908-9. |
format | Online Article Text |
id | pubmed-8918304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89183042022-03-16 12-month survival in nonagenarians inside the Mugello study: on the way to live a century Pancani, Silvia Lombardi, Gemma Sofi, Francesco Gori, Anna Maria Boni, Roberta Castagnoli, Chiara Paperini, Anita Pasquini, Guido Vannetti, Federica Lova, Raffaello Molino Macchi, Claudio Cecchi, Francesca BMC Geriatr Research BACKGROUND: Life expectancy has increased over the last century and a growing number of people is reaching age 90 years and over. However, data on nonagenarians’ health trends are scarce due to difficulties in investigating this specific population. This study aims to identify risk factors for one-year mortality in nonagenarians using data collected within the “Mugello Study”. METHODS: Complete information on sociodemographic data, cognitive and functional status, lifestyle, medical history, and drug use was collected from 433 nonagenarians, as well as information about survival after 1 year from the interview. RESULTS: The sample included 314 women (72.5%) and 119 men (27.5%) with a median age of 92 years (range 90-99 years). The mortality rate was 20.3% (88 deaths). After adjustment for age and sex, a significantly higher risk of dying within 12 months was observed in individuals with more severe cognitive impairment (HR = 5.011, p < 0.001), more severe disability in basic activities of daily living (HR = 4.193, p < 0.001), sedentary lifestyle (HR = 3.367, p < 0.001), higher number of drugs assumed (HR = 1.118, p = 0.031), and kidney dysfunction (HR = 2.609, p = 0.004). When all the variables were included in the analysis, only older age (HR = 1.079, p = 0.048), lower cognitive function (HR = 2.859, p = 0.015), sedentary lifestyle (HR = 2.030, p = 0.026), and kidney dysfunction (HR = 2.322, p = 0.018) remained significantly associated with reduced survival. CONCLUSIONS: Data from the Mugello study support the hypothesis that survival at 12 months in nonagenarians is not a stochastic process and that older age, reduced cognitive function, sedentary lifestyle, and the presence of kidney dysfunction are associated with mortality. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-022-02908-9. BioMed Central 2022-03-12 /pmc/articles/PMC8918304/ /pubmed/35279074 http://dx.doi.org/10.1186/s12877-022-02908-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Pancani, Silvia Lombardi, Gemma Sofi, Francesco Gori, Anna Maria Boni, Roberta Castagnoli, Chiara Paperini, Anita Pasquini, Guido Vannetti, Federica Lova, Raffaello Molino Macchi, Claudio Cecchi, Francesca 12-month survival in nonagenarians inside the Mugello study: on the way to live a century |
title | 12-month survival in nonagenarians inside the Mugello study: on the way to live a century |
title_full | 12-month survival in nonagenarians inside the Mugello study: on the way to live a century |
title_fullStr | 12-month survival in nonagenarians inside the Mugello study: on the way to live a century |
title_full_unstemmed | 12-month survival in nonagenarians inside the Mugello study: on the way to live a century |
title_short | 12-month survival in nonagenarians inside the Mugello study: on the way to live a century |
title_sort | 12-month survival in nonagenarians inside the mugello study: on the way to live a century |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918304/ https://www.ncbi.nlm.nih.gov/pubmed/35279074 http://dx.doi.org/10.1186/s12877-022-02908-9 |
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