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Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder

BACKGROUND: Bipolar disorder (BD) is a multifactorial condition. Several signaling pathways affect development of this disorder. With the purpose of exploring the role of vitamin D receptor (VDR) signaling in this disorder, we measured expression of selected mRNA coding genes and long non-coding RNA...

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Autores principales: Eghtedarian, Reyhane, Ghafouri-Fard, Soudeh, Bouraghi, Hamid, Hussen, Bashdar Mahmud, Arsang-Jang, Shahram, Taheri, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918307/
https://www.ncbi.nlm.nih.gov/pubmed/35279108
http://dx.doi.org/10.1186/s12888-022-03811-8
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author Eghtedarian, Reyhane
Ghafouri-Fard, Soudeh
Bouraghi, Hamid
Hussen, Bashdar Mahmud
Arsang-Jang, Shahram
Taheri, Mohammad
author_facet Eghtedarian, Reyhane
Ghafouri-Fard, Soudeh
Bouraghi, Hamid
Hussen, Bashdar Mahmud
Arsang-Jang, Shahram
Taheri, Mohammad
author_sort Eghtedarian, Reyhane
collection PubMed
description BACKGROUND: Bipolar disorder (BD) is a multifactorial condition. Several signaling pathways affect development of this disorder. With the purpose of exploring the role of vitamin D receptor (VDR) signaling in this disorder, we measured expression of selected mRNA coding genes and long non-coding RNAs (lncRNAs) in this pathway in patients versus normal subjects. METHODS: We measured expression of VDR-associated lncRNAs and mRNAs (SNHG6, MALAT1, Linc00511, Linc00346, VDR and CYP27B1) in the peripheral blood of BD patients vs. healthy individuals. RESULTS: Expression of SNHG6 was significantly higher in cases vs. controls (Posterior beta = 1.29, P value < 0.0001. Subgroup analysis by sex revealed significant results in both subgroups (P value < 0.0001 and P value = 0.023 for males and females, respectively). Expression of CYP27B1 was up-regulated in cases vs. controls (Posterior beta = 0.415, P < 0.0001). Such pattern was also detected among males (P < 0.0001), but not females (P = 0.419). Similarly, MALAT1 and Linc00346 were up-regulated in total cases vs. controls (Posterior beta = 0.694, P < 0.0001 and Posterior beta = 0.4, P = 0.012, respectively) and in male cases compared with male controls (Posterior beta = 0.712, P < 0.0001 and Posterior beta = 0.41, P value = 0.038, respectively). Expression of VDR was up-regulated in total cases compared with controls (Posterior beta = 0.683, P value = 0.001). Finally, expression of Linc00511 was not different between groups. MALAT1, SNHG6, CYP27B1, VDR and Linc00346 had AUC values of 0.95, 0.94, 0.91, 0.85 and 0.83 in differentiation of male patients from controls, respectively. CONCLUSION: The current study suggests VDR-associated genes as possible markers for BD.
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spelling pubmed-89183072022-03-16 Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder Eghtedarian, Reyhane Ghafouri-Fard, Soudeh Bouraghi, Hamid Hussen, Bashdar Mahmud Arsang-Jang, Shahram Taheri, Mohammad BMC Psychiatry Research BACKGROUND: Bipolar disorder (BD) is a multifactorial condition. Several signaling pathways affect development of this disorder. With the purpose of exploring the role of vitamin D receptor (VDR) signaling in this disorder, we measured expression of selected mRNA coding genes and long non-coding RNAs (lncRNAs) in this pathway in patients versus normal subjects. METHODS: We measured expression of VDR-associated lncRNAs and mRNAs (SNHG6, MALAT1, Linc00511, Linc00346, VDR and CYP27B1) in the peripheral blood of BD patients vs. healthy individuals. RESULTS: Expression of SNHG6 was significantly higher in cases vs. controls (Posterior beta = 1.29, P value < 0.0001. Subgroup analysis by sex revealed significant results in both subgroups (P value < 0.0001 and P value = 0.023 for males and females, respectively). Expression of CYP27B1 was up-regulated in cases vs. controls (Posterior beta = 0.415, P < 0.0001). Such pattern was also detected among males (P < 0.0001), but not females (P = 0.419). Similarly, MALAT1 and Linc00346 were up-regulated in total cases vs. controls (Posterior beta = 0.694, P < 0.0001 and Posterior beta = 0.4, P = 0.012, respectively) and in male cases compared with male controls (Posterior beta = 0.712, P < 0.0001 and Posterior beta = 0.41, P value = 0.038, respectively). Expression of VDR was up-regulated in total cases compared with controls (Posterior beta = 0.683, P value = 0.001). Finally, expression of Linc00511 was not different between groups. MALAT1, SNHG6, CYP27B1, VDR and Linc00346 had AUC values of 0.95, 0.94, 0.91, 0.85 and 0.83 in differentiation of male patients from controls, respectively. CONCLUSION: The current study suggests VDR-associated genes as possible markers for BD. BioMed Central 2022-03-12 /pmc/articles/PMC8918307/ /pubmed/35279108 http://dx.doi.org/10.1186/s12888-022-03811-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Eghtedarian, Reyhane
Ghafouri-Fard, Soudeh
Bouraghi, Hamid
Hussen, Bashdar Mahmud
Arsang-Jang, Shahram
Taheri, Mohammad
Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder
title Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder
title_full Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder
title_fullStr Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder
title_full_unstemmed Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder
title_short Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder
title_sort abnormal pattern of vitamin d receptor-associated genes and lncrnas in patients with bipolar disorder
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918307/
https://www.ncbi.nlm.nih.gov/pubmed/35279108
http://dx.doi.org/10.1186/s12888-022-03811-8
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