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Circular RNA in cancer development and immune regulation

Circular RNAs (circRNAs) are a class of single‐stranded RNAs with closed loop structures formed by covalent bonds of head and tail. Exploration of circRNAs is continually increasing; however, their functional relevance largely remains to be elucidated. In general, they are stable, abundant, conserve...

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Detalles Bibliográficos
Autores principales: Li, Weizhen, Liu, Jia‐Qiang, Chen, Ming, Xu, Jiang, Zhu, Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918416/
https://www.ncbi.nlm.nih.gov/pubmed/33277969
http://dx.doi.org/10.1111/jcmm.16102
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author Li, Weizhen
Liu, Jia‐Qiang
Chen, Ming
Xu, Jiang
Zhu, Di
author_facet Li, Weizhen
Liu, Jia‐Qiang
Chen, Ming
Xu, Jiang
Zhu, Di
author_sort Li, Weizhen
collection PubMed
description Circular RNAs (circRNAs) are a class of single‐stranded RNAs with closed loop structures formed by covalent bonds of head and tail. Exploration of circRNAs is continually increasing; however, their functional relevance largely remains to be elucidated. In general, they are stable, abundant, conserved and expressed in tissue‐specific manner. These distinct properties and their diverse cellular actions indicate that circRNAs modulate transcription and translation, and may even function as translation templates. Growing evidence reveals that circRNAs contribute to various physiological and pathological processes, including the initiation and progression of cancer. In this review, we present the current knowledge about circRNAs in cancer development, as well as their potential for use as biomarkers and even therapeutic targets. CircRNA’s role in immune regulation and antitumour immunotherapy is also discussed. In addition, possible challenges in antitumour therapy are raised, and current progress and future perspectives are provided.
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spelling pubmed-89184162022-03-18 Circular RNA in cancer development and immune regulation Li, Weizhen Liu, Jia‐Qiang Chen, Ming Xu, Jiang Zhu, Di J Cell Mol Med Review Circular RNAs (circRNAs) are a class of single‐stranded RNAs with closed loop structures formed by covalent bonds of head and tail. Exploration of circRNAs is continually increasing; however, their functional relevance largely remains to be elucidated. In general, they are stable, abundant, conserved and expressed in tissue‐specific manner. These distinct properties and their diverse cellular actions indicate that circRNAs modulate transcription and translation, and may even function as translation templates. Growing evidence reveals that circRNAs contribute to various physiological and pathological processes, including the initiation and progression of cancer. In this review, we present the current knowledge about circRNAs in cancer development, as well as their potential for use as biomarkers and even therapeutic targets. CircRNA’s role in immune regulation and antitumour immunotherapy is also discussed. In addition, possible challenges in antitumour therapy are raised, and current progress and future perspectives are provided. John Wiley and Sons Inc. 2020-12-05 2022-03 /pmc/articles/PMC8918416/ /pubmed/33277969 http://dx.doi.org/10.1111/jcmm.16102 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Li, Weizhen
Liu, Jia‐Qiang
Chen, Ming
Xu, Jiang
Zhu, Di
Circular RNA in cancer development and immune regulation
title Circular RNA in cancer development and immune regulation
title_full Circular RNA in cancer development and immune regulation
title_fullStr Circular RNA in cancer development and immune regulation
title_full_unstemmed Circular RNA in cancer development and immune regulation
title_short Circular RNA in cancer development and immune regulation
title_sort circular rna in cancer development and immune regulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918416/
https://www.ncbi.nlm.nih.gov/pubmed/33277969
http://dx.doi.org/10.1111/jcmm.16102
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