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Circular RNA in cancer development and immune regulation
Circular RNAs (circRNAs) are a class of single‐stranded RNAs with closed loop structures formed by covalent bonds of head and tail. Exploration of circRNAs is continually increasing; however, their functional relevance largely remains to be elucidated. In general, they are stable, abundant, conserve...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918416/ https://www.ncbi.nlm.nih.gov/pubmed/33277969 http://dx.doi.org/10.1111/jcmm.16102 |
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author | Li, Weizhen Liu, Jia‐Qiang Chen, Ming Xu, Jiang Zhu, Di |
author_facet | Li, Weizhen Liu, Jia‐Qiang Chen, Ming Xu, Jiang Zhu, Di |
author_sort | Li, Weizhen |
collection | PubMed |
description | Circular RNAs (circRNAs) are a class of single‐stranded RNAs with closed loop structures formed by covalent bonds of head and tail. Exploration of circRNAs is continually increasing; however, their functional relevance largely remains to be elucidated. In general, they are stable, abundant, conserved and expressed in tissue‐specific manner. These distinct properties and their diverse cellular actions indicate that circRNAs modulate transcription and translation, and may even function as translation templates. Growing evidence reveals that circRNAs contribute to various physiological and pathological processes, including the initiation and progression of cancer. In this review, we present the current knowledge about circRNAs in cancer development, as well as their potential for use as biomarkers and even therapeutic targets. CircRNA’s role in immune regulation and antitumour immunotherapy is also discussed. In addition, possible challenges in antitumour therapy are raised, and current progress and future perspectives are provided. |
format | Online Article Text |
id | pubmed-8918416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89184162022-03-18 Circular RNA in cancer development and immune regulation Li, Weizhen Liu, Jia‐Qiang Chen, Ming Xu, Jiang Zhu, Di J Cell Mol Med Review Circular RNAs (circRNAs) are a class of single‐stranded RNAs with closed loop structures formed by covalent bonds of head and tail. Exploration of circRNAs is continually increasing; however, their functional relevance largely remains to be elucidated. In general, they are stable, abundant, conserved and expressed in tissue‐specific manner. These distinct properties and their diverse cellular actions indicate that circRNAs modulate transcription and translation, and may even function as translation templates. Growing evidence reveals that circRNAs contribute to various physiological and pathological processes, including the initiation and progression of cancer. In this review, we present the current knowledge about circRNAs in cancer development, as well as their potential for use as biomarkers and even therapeutic targets. CircRNA’s role in immune regulation and antitumour immunotherapy is also discussed. In addition, possible challenges in antitumour therapy are raised, and current progress and future perspectives are provided. John Wiley and Sons Inc. 2020-12-05 2022-03 /pmc/articles/PMC8918416/ /pubmed/33277969 http://dx.doi.org/10.1111/jcmm.16102 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Li, Weizhen Liu, Jia‐Qiang Chen, Ming Xu, Jiang Zhu, Di Circular RNA in cancer development and immune regulation |
title | Circular RNA in cancer development and immune regulation |
title_full | Circular RNA in cancer development and immune regulation |
title_fullStr | Circular RNA in cancer development and immune regulation |
title_full_unstemmed | Circular RNA in cancer development and immune regulation |
title_short | Circular RNA in cancer development and immune regulation |
title_sort | circular rna in cancer development and immune regulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918416/ https://www.ncbi.nlm.nih.gov/pubmed/33277969 http://dx.doi.org/10.1111/jcmm.16102 |
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