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Broadband 75–85 MHz radiofrequency fields disrupt magnetic compass orientation in night-migratory songbirds consistent with a flavin-based radical pair magnetoreceptor
The light-dependent magnetic compass sense of night-migratory songbirds can be disrupted by weak radiofrequency fields. This finding supports a quantum mechanical, radical-pair-based mechanism of magnetoreception as observed for isolated cryptochrome 4, a protein found in birds’ retinas. The exact i...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918455/ https://www.ncbi.nlm.nih.gov/pubmed/35019998 http://dx.doi.org/10.1007/s00359-021-01537-8 |
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author | Leberecht, Bo Kobylkov, Dmitry Karwinkel, Thiemo Döge, Sara Burnus, Lars Wong, Siu Ying Apte, Shambhavi Haase, Katrin Musielak, Isabelle Chetverikova, Raisa Dautaj, Glen Bassetto, Marco Winklhofer, Michael Hore, P. J. Mouritsen, Henrik |
author_facet | Leberecht, Bo Kobylkov, Dmitry Karwinkel, Thiemo Döge, Sara Burnus, Lars Wong, Siu Ying Apte, Shambhavi Haase, Katrin Musielak, Isabelle Chetverikova, Raisa Dautaj, Glen Bassetto, Marco Winklhofer, Michael Hore, P. J. Mouritsen, Henrik |
author_sort | Leberecht, Bo |
collection | PubMed |
description | The light-dependent magnetic compass sense of night-migratory songbirds can be disrupted by weak radiofrequency fields. This finding supports a quantum mechanical, radical-pair-based mechanism of magnetoreception as observed for isolated cryptochrome 4, a protein found in birds’ retinas. The exact identity of the magnetically sensitive radicals in cryptochrome is uncertain in vivo, but their formation seems to require a bound flavin adenine dinucleotide chromophore and a chain of four tryptophan residues within the protein. Resulting from the hyperfine interactions of nuclear spins with the unpaired electrons, the sensitivity of the radicals to radiofrequency magnetic fields depends strongly on the number of magnetic nuclei (hydrogen and nitrogen atoms) they contain. Quantum-chemical calculations suggested that electromagnetic noise in the frequency range 75–85 MHz could give information about the identity of the radicals involved. Here, we show that broadband 75–85 MHz radiofrequency fields prevent a night-migratory songbird from using its magnetic compass in behavioural experiments. These results indicate that at least one of the components of the radical pair involved in the sensory process of avian magnetoreception must contain a substantial number of strong hyperfine interactions as would be the case if a flavin–tryptophan radical pair were the magnetic sensor. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00359-021-01537-8. |
format | Online Article Text |
id | pubmed-8918455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-89184552022-03-17 Broadband 75–85 MHz radiofrequency fields disrupt magnetic compass orientation in night-migratory songbirds consistent with a flavin-based radical pair magnetoreceptor Leberecht, Bo Kobylkov, Dmitry Karwinkel, Thiemo Döge, Sara Burnus, Lars Wong, Siu Ying Apte, Shambhavi Haase, Katrin Musielak, Isabelle Chetverikova, Raisa Dautaj, Glen Bassetto, Marco Winklhofer, Michael Hore, P. J. Mouritsen, Henrik J Comp Physiol A Neuroethol Sens Neural Behav Physiol Original Paper The light-dependent magnetic compass sense of night-migratory songbirds can be disrupted by weak radiofrequency fields. This finding supports a quantum mechanical, radical-pair-based mechanism of magnetoreception as observed for isolated cryptochrome 4, a protein found in birds’ retinas. The exact identity of the magnetically sensitive radicals in cryptochrome is uncertain in vivo, but their formation seems to require a bound flavin adenine dinucleotide chromophore and a chain of four tryptophan residues within the protein. Resulting from the hyperfine interactions of nuclear spins with the unpaired electrons, the sensitivity of the radicals to radiofrequency magnetic fields depends strongly on the number of magnetic nuclei (hydrogen and nitrogen atoms) they contain. Quantum-chemical calculations suggested that electromagnetic noise in the frequency range 75–85 MHz could give information about the identity of the radicals involved. Here, we show that broadband 75–85 MHz radiofrequency fields prevent a night-migratory songbird from using its magnetic compass in behavioural experiments. These results indicate that at least one of the components of the radical pair involved in the sensory process of avian magnetoreception must contain a substantial number of strong hyperfine interactions as would be the case if a flavin–tryptophan radical pair were the magnetic sensor. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00359-021-01537-8. Springer Berlin Heidelberg 2022-01-12 2022 /pmc/articles/PMC8918455/ /pubmed/35019998 http://dx.doi.org/10.1007/s00359-021-01537-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Paper Leberecht, Bo Kobylkov, Dmitry Karwinkel, Thiemo Döge, Sara Burnus, Lars Wong, Siu Ying Apte, Shambhavi Haase, Katrin Musielak, Isabelle Chetverikova, Raisa Dautaj, Glen Bassetto, Marco Winklhofer, Michael Hore, P. J. Mouritsen, Henrik Broadband 75–85 MHz radiofrequency fields disrupt magnetic compass orientation in night-migratory songbirds consistent with a flavin-based radical pair magnetoreceptor |
title | Broadband 75–85 MHz radiofrequency fields disrupt magnetic compass orientation in night-migratory songbirds consistent with a flavin-based radical pair magnetoreceptor |
title_full | Broadband 75–85 MHz radiofrequency fields disrupt magnetic compass orientation in night-migratory songbirds consistent with a flavin-based radical pair magnetoreceptor |
title_fullStr | Broadband 75–85 MHz radiofrequency fields disrupt magnetic compass orientation in night-migratory songbirds consistent with a flavin-based radical pair magnetoreceptor |
title_full_unstemmed | Broadband 75–85 MHz radiofrequency fields disrupt magnetic compass orientation in night-migratory songbirds consistent with a flavin-based radical pair magnetoreceptor |
title_short | Broadband 75–85 MHz radiofrequency fields disrupt magnetic compass orientation in night-migratory songbirds consistent with a flavin-based radical pair magnetoreceptor |
title_sort | broadband 75–85 mhz radiofrequency fields disrupt magnetic compass orientation in night-migratory songbirds consistent with a flavin-based radical pair magnetoreceptor |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918455/ https://www.ncbi.nlm.nih.gov/pubmed/35019998 http://dx.doi.org/10.1007/s00359-021-01537-8 |
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