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Toxic Epidermal Necrolysis associated with COVID‐19 infection: A case report

Toxic Epidermal Necrolysis/Steven–Johnson Syndrome (TEN/SJS) is one of the most serious dermatological adverse reactions triggered mainly by drugs and less likely by infections. COVID‐19 disease is caused by Sever Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) with a wide range of clinical ma...

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Autores principales: Jouhar, Lamia, Yahya, Marva, Elsiddiq, Sohair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918465/
https://www.ncbi.nlm.nih.gov/pubmed/35310321
http://dx.doi.org/10.1002/ccr3.5565
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author Jouhar, Lamia
Yahya, Marva
Elsiddiq, Sohair
author_facet Jouhar, Lamia
Yahya, Marva
Elsiddiq, Sohair
author_sort Jouhar, Lamia
collection PubMed
description Toxic Epidermal Necrolysis/Steven–Johnson Syndrome (TEN/SJS) is one of the most serious dermatological adverse reactions triggered mainly by drugs and less likely by infections. COVID‐19 disease is caused by Sever Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) with a wide range of clinical manifestations. Skin involvement is common in COVID‐19 patients including urticaria, purpura, and vasculitis. There were reported cases of TEN/SJS in adults with COVID‐19 infections and only two reported cases in pediatric patients. The causality relationship between COVID‐19 infection and TEN/SJS was not established in most cases due to history of drug usage that could be the trigger. In this study, we are reporting a case of previously healthy child apart from COVID‐19 infection who was admitted to the intensive care unit with TEN involving more than 30% of body surface area confirmed by skin biopsy. The child was treated with intravenous immunoglobulins, steroids, and cyclosporin with a very good outcome.
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spelling pubmed-89184652022-03-18 Toxic Epidermal Necrolysis associated with COVID‐19 infection: A case report Jouhar, Lamia Yahya, Marva Elsiddiq, Sohair Clin Case Rep Case Reports Toxic Epidermal Necrolysis/Steven–Johnson Syndrome (TEN/SJS) is one of the most serious dermatological adverse reactions triggered mainly by drugs and less likely by infections. COVID‐19 disease is caused by Sever Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) with a wide range of clinical manifestations. Skin involvement is common in COVID‐19 patients including urticaria, purpura, and vasculitis. There were reported cases of TEN/SJS in adults with COVID‐19 infections and only two reported cases in pediatric patients. The causality relationship between COVID‐19 infection and TEN/SJS was not established in most cases due to history of drug usage that could be the trigger. In this study, we are reporting a case of previously healthy child apart from COVID‐19 infection who was admitted to the intensive care unit with TEN involving more than 30% of body surface area confirmed by skin biopsy. The child was treated with intravenous immunoglobulins, steroids, and cyclosporin with a very good outcome. John Wiley and Sons Inc. 2022-03-13 /pmc/articles/PMC8918465/ /pubmed/35310321 http://dx.doi.org/10.1002/ccr3.5565 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Jouhar, Lamia
Yahya, Marva
Elsiddiq, Sohair
Toxic Epidermal Necrolysis associated with COVID‐19 infection: A case report
title Toxic Epidermal Necrolysis associated with COVID‐19 infection: A case report
title_full Toxic Epidermal Necrolysis associated with COVID‐19 infection: A case report
title_fullStr Toxic Epidermal Necrolysis associated with COVID‐19 infection: A case report
title_full_unstemmed Toxic Epidermal Necrolysis associated with COVID‐19 infection: A case report
title_short Toxic Epidermal Necrolysis associated with COVID‐19 infection: A case report
title_sort toxic epidermal necrolysis associated with covid‐19 infection: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918465/
https://www.ncbi.nlm.nih.gov/pubmed/35310321
http://dx.doi.org/10.1002/ccr3.5565
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