Cargando…

Non-Canonical Amino Acid-Based Engineering of (R)-Amine Transaminase

Non-canonical amino acids (ncAAs) have been utilized as an invaluable tool for modulating the active site of the enzymes, probing the complex enzyme mechanisms, improving catalytic activity, and designing new to nature enzymes. Here, we report site-specific incorporation of p-benzoyl phenylalanine (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pagar, Amol D., Jeon, Hyunwoo, Khobragade, Taresh P., Sarak, Sharad, Giri, Pritam, Lim, Seonga, Yoo, Tae Hyeon, Ko, Byoung Joon, Yun, Hyungdon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918476/ https://www.ncbi.nlm.nih.gov/pubmed/35295971 http://dx.doi.org/10.3389/fchem.2022.839636

Ejemplares similares

Synthesis of Sitagliptin Intermediate by a Multi-Enzymatic Cascade System Using Lipase and Transaminase With Benzylamine as an Amino Donor
por: Khobragade, Taresh P., et al.
Publicado: (2021)

Dual-function transaminases with hybrid nanoflower for the production of value-added chemicals from biobased levulinic acid
por: Khobragade, Taresh P., et al.
Publicado: (2023)

Direct Conversion of Hydrazones to Amines using Transaminases
por: Carter, Eve M., et al.
Publicado: (2021)

Structural dynamics of the transaminase active site revealed by the crystal structure of a co-factor free omega-transaminase from Vibrio fluvialis JS17
por: Shin, Young-Cheul, et al.
Publicado: (2018)

Transaminase-Mediated Amine Borrowing via Shuttle Biocatalysis
por: Taday, Freya, et al.
Publicado: (2021)

Alteration of the Donor/Acceptor Spectrum of the (S)-Amine Transaminase from Vibrio fluvialis
por: Genz, Maika, et al.
Publicado: (2015)

A new target region for changing the substrate specificity of amine transaminases
por: Guan, Li-Jun, et al.
Publicado: (2015)

Aminopolyols from Carbohydrates: Amination of Sugars and Sugar‐Derived Tetrahydrofurans with Transaminases
por: Subrizi, Fabiana, et al.
Publicado: (2019)

Insight into the dimer dissociation process of the Chromobacterium violaceum (S)-selective amine transaminase
por: Ruggieri, Federica, et al.
Publicado: (2019)

Transaminases for the synthesis of enantiopure beta-amino acids
por: Rudat, Jens, et al.
Publicado: (2012)

Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor that Displaces Equilibria and Enables High-Throughput Screening**
por: Green, Anthony P, et al.
Publicado: (2014)

A Single Mutation Increases the Thermostability and Activity of Aspergillus terreus Amine Transaminase
por: Zhu, Wan-Li, et al.
Publicado: (2019)

Expanding the Toolbox of R‐Selective Amine Transaminases by Identification and Characterization of New Members
por: Telzerow, Aline, et al.
Publicado: (2020)

Structural basis of substrate recognition by a novel thermostable (S)-enantioselective ω-transaminase from Thermomicrobium roseum
por: Kwon, Sunghark, et al.
Publicado: (2019)

Expanded Substrate Specificity in D-Amino Acid Transaminases: A Case Study of Transaminase from Blastococcus saxobsidens
por: Shilova, Sofia A., et al.
Publicado: (2023)

Biocatalytic Production of Amino Carbohydrates through Oxidoreductase and Transaminase Cascades
por: Aumala, Ville, et al.
Publicado: (2019)

The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase from Nectria haematococca
por: Sayer, Christopher, et al.
Publicado: (2014)

Asymmetric synthesis of a high added value chiral amine using immobilized ω-transaminases
por: Petri, Antonella, et al.
Publicado: (2019)

Computational Redesign of an ω-Transaminase from Pseudomonas jessenii for Asymmetric Synthesis of Enantiopure Bulky Amines
por: Meng, Qinglong, et al.
Publicado: (2021)

Computer Modeling Explains the Structural Reasons for the Difference in Reactivity of Amine Transaminases Regarding Prochiral Methylketones
por: Teixeira, Iris S., et al.
Publicado: (2022)

GPhos Ligand Enables Production of Chiral N‐Arylamines in a Telescoped Transaminase‐Buchwald‐Hartwig Amination Cascade in the Presence of Excess Amine Donor
por: Heckmann, Christian M., et al.
Publicado: (2021)

Characterization of proteins from the 3N5M family reveals an operationally stable amine transaminase
por: Kollipara, Manideep, et al.
Publicado: (2022)

A Machine Learning Study on the Thermostability Prediction of (R)-ω-Selective Amine Transaminase from Aspergillus terreus
por: Jia, Li-li, et al.
Publicado: (2021)

Transaminase-mediated synthesis of enantiopure drug-like 1-(3′,4′-disubstituted phenyl)propan-2-amines
por: Lakó, Ágnes, et al.
Publicado: (2020)

Phenotypical characterisation of a putative ω-amino acid transaminase in the yeast Scheffersomyces stipitis
por: Linder, Tomas
Publicado: (2018)

Fusion of Formate Dehydrogenase and Alanine Dehydrogenase as an Amino Donor Regenerating System Coupled to Transaminases
por: Marchini, Valentina, et al.
Publicado: (2022)

Clinical Significance of Pre-to-Postoperative Dynamics of Aspartate Transaminase/Alanine Transaminase Ratio in Predicting the Prognosis of Renal Cell Carcinoma after Surgical Treatment
por: Kang, Minyong, et al.
Publicado: (2020)

A transaminase with β-activity from Variovorax boronicumulans for the production of enantiopure β-amino acids
por: Wegner, Uwe, et al.
Publicado: (2022)

Enhancing a Sphaerobacter thermophilus ω-transaminase for kinetic resolution of β- and γ-amino acids
por: Wegner, Uwe, et al.
Publicado: (2023)

B‐factor Guided Proline Substitutions in Chromobacterium violaceum Amine Transaminase: Evaluation of the Proline Rule as a Method for Enzyme Stabilization
por: Land, Henrik, et al.
Publicado: (2019)

Enzymatic and chemo-enzymatic strategies to produce highly valuable chiral amines from biomass with ω-transaminases on 2D zeolites
por: Carceller, J Miguel, et al.
Publicado: (2022)

Single point mutations reveal amino acid residues important for Chromobacterium violaceum transaminase activity in the production of unnatural amino acids
por: Almahboub, Sarah A., et al.
Publicado: (2018)

De Ritis Ratio (Aspartate Transaminase/Alanine Transaminase) as a Significant Prognostic Factor in Patients Undergoing Radical Cystectomy with Bladder Urothelial Carcinoma: A Propensity Score-Matched Study
por: Yuk, Hyeong Dong, et al.
Publicado: (2019)

A Rise in Aspartate Transaminase and Alanine Transaminase Associated With Ondansetron Administration in a Pregnant Female
por: Couse, Michael, et al.
Publicado: (2020)

A cross-sectional study to assess concerns and commitment for organ donation among students of arts, science and commerce streams in degree colleges in a metropolitan city
por: Kinge, Amol, et al.
Publicado: (2022)

Metabolomic profiling of amines in sepsis predicts changes in NOS canonical pathways
por: Tesfai, Abel, et al.
Publicado: (2017)

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids
por: Martino, Michael R., et al.
Publicado: (2022)

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids
por: Martino, Michael R., et al.
Publicado: (2022)

To the Understanding of Catalysis by D-Amino Acid Transaminases: A Case Study of the Enzyme from Aminobacterium colombiense
por: Shilova, Sofia A., et al.
Publicado: (2023)

Analysis of interaction between intracellular spermine and transient receptor potential canonical 4 channel: multiple candidate sites of negatively charged amino acids for the inward rectification of transient receptor potential canonical 4
por: Kim, Jinsung, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6itd5kvkso5n01bhjnf7aop6ej