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Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors

Many studies already reported on the association between patient characteristics on the severity of COVID-19 disease outcome, but the relation with SARS-CoV-2 antibody levels is less clear. To investigate this in more detail, we performed a retrospective observational study in which we used the IgG...

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Autores principales: Vinkenoog, Marieke, Steenhuis, Maurice, Brinke, Anja ten, van Hasselt, J. G. Coen, Janssen, Mart P., van Leeuwen, Matthijs, Swaneveld, Francis H., Vrielink, Hans, van de Watering, Leo, Quee, Franke, van den Hurk, Katja, Rispens, Theo, Hogema, Boris, van der Schoot, C. Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918483/
https://www.ncbi.nlm.nih.gov/pubmed/35296077
http://dx.doi.org/10.3389/fimmu.2022.821721
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author Vinkenoog, Marieke
Steenhuis, Maurice
Brinke, Anja ten
van Hasselt, J. G. Coen
Janssen, Mart P.
van Leeuwen, Matthijs
Swaneveld, Francis H.
Vrielink, Hans
van de Watering, Leo
Quee, Franke
van den Hurk, Katja
Rispens, Theo
Hogema, Boris
van der Schoot, C. Ellen
author_facet Vinkenoog, Marieke
Steenhuis, Maurice
Brinke, Anja ten
van Hasselt, J. G. Coen
Janssen, Mart P.
van Leeuwen, Matthijs
Swaneveld, Francis H.
Vrielink, Hans
van de Watering, Leo
Quee, Franke
van den Hurk, Katja
Rispens, Theo
Hogema, Boris
van der Schoot, C. Ellen
author_sort Vinkenoog, Marieke
collection PubMed
description Many studies already reported on the association between patient characteristics on the severity of COVID-19 disease outcome, but the relation with SARS-CoV-2 antibody levels is less clear. To investigate this in more detail, we performed a retrospective observational study in which we used the IgG antibody response from 11,118 longitudinal antibody measurements of 2,082 unique COVID convalescent plasma donors. COVID-19 symptoms and donor characteristics were obtained by a questionnaire. Antibody responses were modelled using a linear mixed-effects model. Our study confirms that the SARS-CoV-2 antibody response is associated with patient characteristics like body mass index and age. Antibody decay was faster in male than in female donors (average half-life of 62 versus 72 days). Most interestingly, we also found that three symptoms (headache, anosmia, nasal cold) were associated with lower peak IgG, while six other symptoms (dry cough, fatigue, diarrhoea, fever, dyspnoea, muscle weakness) were associated with higher IgG concentrations.
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spelling pubmed-89184832022-03-15 Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors Vinkenoog, Marieke Steenhuis, Maurice Brinke, Anja ten van Hasselt, J. G. Coen Janssen, Mart P. van Leeuwen, Matthijs Swaneveld, Francis H. Vrielink, Hans van de Watering, Leo Quee, Franke van den Hurk, Katja Rispens, Theo Hogema, Boris van der Schoot, C. Ellen Front Immunol Immunology Many studies already reported on the association between patient characteristics on the severity of COVID-19 disease outcome, but the relation with SARS-CoV-2 antibody levels is less clear. To investigate this in more detail, we performed a retrospective observational study in which we used the IgG antibody response from 11,118 longitudinal antibody measurements of 2,082 unique COVID convalescent plasma donors. COVID-19 symptoms and donor characteristics were obtained by a questionnaire. Antibody responses were modelled using a linear mixed-effects model. Our study confirms that the SARS-CoV-2 antibody response is associated with patient characteristics like body mass index and age. Antibody decay was faster in male than in female donors (average half-life of 62 versus 72 days). Most interestingly, we also found that three symptoms (headache, anosmia, nasal cold) were associated with lower peak IgG, while six other symptoms (dry cough, fatigue, diarrhoea, fever, dyspnoea, muscle weakness) were associated with higher IgG concentrations. Frontiers Media S.A. 2022-02-28 /pmc/articles/PMC8918483/ /pubmed/35296077 http://dx.doi.org/10.3389/fimmu.2022.821721 Text en Copyright © 2022 Vinkenoog, Steenhuis, Brinke, van Hasselt, Janssen, van Leeuwen, Swaneveld, Vrielink, van de Watering, Quee, van den Hurk, Rispens, Hogema and van der Schoot https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Vinkenoog, Marieke
Steenhuis, Maurice
Brinke, Anja ten
van Hasselt, J. G. Coen
Janssen, Mart P.
van Leeuwen, Matthijs
Swaneveld, Francis H.
Vrielink, Hans
van de Watering, Leo
Quee, Franke
van den Hurk, Katja
Rispens, Theo
Hogema, Boris
van der Schoot, C. Ellen
Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors
title Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors
title_full Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors
title_fullStr Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors
title_full_unstemmed Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors
title_short Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors
title_sort associations between symptoms, donor characteristics and igg antibody response in 2082 covid-19 convalescent plasma donors
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918483/
https://www.ncbi.nlm.nih.gov/pubmed/35296077
http://dx.doi.org/10.3389/fimmu.2022.821721
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