Cargando…

Single-Cell RNA-Seq Analysis Reveals Macrophage Involved in the Progression of Human Intervertebral Disc Degeneration

Intervertebral disc degeneration (IDD) has been considered as the primary pathological mechanism that underlies low back pain. Understanding the molecular mechanisms underlying human IDD is imperative for making strategies to treat IDD-related diseases. Herein, we report the molecular programs, line...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ling, Zemin, Liu, Yong, Wang, Zhe, Zhang, Ziji, Chen, Bolin, Yang, Jiaming, Zeng, Baozhu, Gao, Yu, Jiang, Chang, Huang, Yulin, Zou, Xuenong, Wang, Xiuhui, Wei, Fuxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918513/ https://www.ncbi.nlm.nih.gov/pubmed/35295968 http://dx.doi.org/10.3389/fcell.2021.833420

Ejemplares similares

Elimination of Senescent Cells by Senolytics Facilitates Bony Endplate Microvessel Formation and Mitigates Disc Degeneration in Aged Mice
por: Chen, Bolin, et al.
Publicado: (2022)

The role of ferroptosis in intervertebral disc degeneration
por: Fan, Chunyang, et al.
Publicado: (2023)

Cationic Polymer Brush-Modified Carbon Nanotube-Meditated eRNA LINC02569 Silencing Attenuates Nucleus Pulposus Degeneration by Blocking NF-κB Signaling Pathway and Alleviate Cell Senescence
por: Huang, Yulin, et al.
Publicado: (2022)

Oxidative Stress and Intervertebral Disc Degeneration: Pathophysiology, Signaling Pathway, and Therapy
por: Li, Yanrun, et al.
Publicado: (2022)

Endoplasmic Reticulum Stress: An Emerging Therapeutic Target for Intervertebral Disc Degeneration
por: Wang, Dong, et al.
Publicado: (2022)

Exosomes Immunity Strategy: A Novel Approach for Ameliorating Intervertebral Disc Degeneration
por: Li, Weihang, et al.
Publicado: (2022)

Umbilical cord mesenchymal stem cells for regenerative treatment of intervertebral disc degeneration
por: Huang, Huagui, et al.
Publicado: (2023)

Fexofenadine Protects Against Intervertebral Disc Degeneration Through TNF Signaling
por: Liu, Kaiwen, et al.
Publicado: (2021)

Extracellular Vesicles Derived From Stem Cells in Intervertebral Disc Degeneration
por: Wu, Xinjie, et al.
Publicado: (2022)

Editorial: Immunological imbalance: What is its role in intervertebral disc degeneration?
por: Gantenbein, Benjamin, et al.
Publicado: (2023)

In vivo experimental intervertebral disc degeneration induced by bleomycin in the rhesus monkey
por: Wei, Fuxin, et al.
Publicado: (2014)

PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells
por: Zhang, Zhenlei, et al.
Publicado: (2022)

Circ_0005918 Sponges miR-622 to Aggravate Intervertebral Disc Degeneration
por: Cui, Yan, et al.
Publicado: (2022)

Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway
por: Wang, Dong, et al.
Publicado: (2020)

The new ceRNA crosstalk between mRNAs and miRNAs in intervertebral disc degeneration
por: Li, Xingye, et al.
Publicado: (2022)

Role of ferroptosis and immune infiltration in intervertebral disc degeneration: novel insights from bioinformatics analyses
por: Liu, Xiao-Wei, et al.
Publicado: (2023)

Mesenchymal Stem Cell-Derived Exosomes as a Novel Strategy for the Treatment of Intervertebral Disc Degeneration
por: Lu, Lin, et al.
Publicado: (2022)

Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells
por: Xie, Chenglong, et al.
Publicado: (2022)

Panax notoginseng saponins attenuate intervertebral disc degeneration by reducing the end plate porosity in lumbar spinal instability mice
por: Hu, Hao, et al.
Publicado: (2021)

The Role of miR-31-5p in the Development of Intervertebral Disc Degeneration and Its Therapeutic Potential
por: Zhou, Yong, et al.
Publicado: (2021)

Macrophages and Intervertebral Disc Degeneration
por: Koroth, Jinsha, et al.
Publicado: (2023)

Single-Cell RNA Sequencing of the Nucleus Pulposus Reveals Chondrocyte Differentiation and Regulation in Intervertebral Disc Degeneration
por: Han, Shuo, et al.
Publicado: (2022)

Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin
por: Xu, Haoran, et al.
Publicado: (2021)

Autophagy-Based Unconventional Secretory for AIM2 Inflammasome Drives DNA Damage Resistance During Intervertebral Disc Degeneration
por: Li, Shuai, et al.
Publicado: (2021)

Mechanism of Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration
por: Liang, Weishi, et al.
Publicado: (2022)

The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review
por: Suyama, Kaori, et al.
Publicado: (2022)

Changes of the end plate cartilage are associated with intervertebral disc degeneration: A quantitative magnetic resonance imaging study in rhesus monkeys and humans
por: Ling, Zemin, et al.
Publicado: (2020)

IGF Signaling in Intervertebral Disc Health and Disease
por: Lin, Hui, et al.
Publicado: (2022)

Immuno-Modulatory Effects of Intervertebral Disc Cells
por: Bermudez-Lekerika, Paola, et al.
Publicado: (2022)

RNA-Binding Protein HuR Suppresses Inflammation and Promotes Extracellular Matrix Homeostasis via NKRF in Intervertebral Disc Degeneration
por: Shao, Zhenxuan, et al.
Publicado: (2020)

Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis
por: Lin, Zhen, et al.
Publicado: (2021)

Cholesterol Induces Pyroptosis and Matrix Degradation via mSREBP1-Driven Endoplasmic Reticulum Stress in Intervertebral Disc Degeneration
por: Yan, Jiansen, et al.
Publicado: (2022)

Causal association of physical activity with low back pain, intervertebral disc degeneration and sciatica: a two-sample mendelian randomization analysis study
por: Guan, Xiaoqing, et al.
Publicado: (2023)

Single Impact Injury of Vertebral Endplates Without Structural Disruption, Initiates Disc Degeneration Through Piezo1 Mediated Inflammation and Metabolism Dysfunction
por: Sun, Zhengang, et al.
Publicado: (2022)

Arginase II Promotes Intervertebral Disc Degeneration Through Exacerbating Senescence and Apoptosis Caused by Oxidative Stress and Inflammation via the NF-κB Pathway
por: Li, Fudong, et al.
Publicado: (2021)

Integrated proteome sequencing, bulk RNA sequencing and single-cell RNA sequencing to identify potential biomarkers in different grades of intervertebral disc degeneration
por: Yang, Xiao, et al.
Publicado: (2023)

Senotherapeutic drugs for human intervertebral disc degeneration and low back pain
por: Cherif, Hosni, et al.
Publicado: (2020)

Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration
por: Bach, Frances C., et al.
Publicado: (2022)

Degeneration of the intervertebral disc
por: Urban, Jill PG, et al.
Publicado: (2003)

Treatment of Intervertebral Disc Degeneration
por: Xin, Jingguo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uf4j8o6mjgdn692p2njase7dgm