The Role of Circular RNAs in the Carcinogenesis of Bladder Cancer

Circular RNAs (circRNAs) are a group of transcripts with enclosed configurations which can regulate gene expression. These transcripts have important roles in normal development and in the pathogenesis of disorders. Recent evidence has supported involvement of circRNAs in the development of bladder...

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Autores principales: Ghafouri-Fard, Soudeh, Najafi, Sajad, Hussen, Bashdar Mahmud, Basiri, Abbas, Hidayat, Hazha Jamal, Taheri, Mohammad, Rashnoo, Fariborz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918517/
https://www.ncbi.nlm.nih.gov/pubmed/35296022
http://dx.doi.org/10.3389/fonc.2022.801842
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author Ghafouri-Fard, Soudeh
Najafi, Sajad
Hussen, Bashdar Mahmud
Basiri, Abbas
Hidayat, Hazha Jamal
Taheri, Mohammad
Rashnoo, Fariborz
author_facet Ghafouri-Fard, Soudeh
Najafi, Sajad
Hussen, Bashdar Mahmud
Basiri, Abbas
Hidayat, Hazha Jamal
Taheri, Mohammad
Rashnoo, Fariborz
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description Circular RNAs (circRNAs) are a group of transcripts with enclosed configurations which can regulate gene expression. These transcripts have important roles in normal development and in the pathogenesis of disorders. Recent evidence has supported involvement of circRNAs in the development of bladder cancer. Several circRNAs such as circ_0058063, hsa-circRNA-403658, circPDSS1, circCASC15, circRNA-MYLK, and circRNA_103809 have been upregulated in bladder cancer samples. On the other hand, hsa_circ_0137606, BCRC-3, circFUT8, hsa_circ_001598, circSLC8A1, hsa_circ_0077837, hsa_circ_0004826, and circACVR2A are among downregulated circRNAs in bladder cancer. Numerous circRNAs have diagnostic or prognostic value in bladder cancer. In this review, we aim to outline the latest findings about the role of circRNAs in bladder cancer and introduce circRNAs for further investigations as therapeutic targets.
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spelling pubmed-89185172022-03-15 The Role of Circular RNAs in the Carcinogenesis of Bladder Cancer Ghafouri-Fard, Soudeh Najafi, Sajad Hussen, Bashdar Mahmud Basiri, Abbas Hidayat, Hazha Jamal Taheri, Mohammad Rashnoo, Fariborz Front Oncol Oncology Circular RNAs (circRNAs) are a group of transcripts with enclosed configurations which can regulate gene expression. These transcripts have important roles in normal development and in the pathogenesis of disorders. Recent evidence has supported involvement of circRNAs in the development of bladder cancer. Several circRNAs such as circ_0058063, hsa-circRNA-403658, circPDSS1, circCASC15, circRNA-MYLK, and circRNA_103809 have been upregulated in bladder cancer samples. On the other hand, hsa_circ_0137606, BCRC-3, circFUT8, hsa_circ_001598, circSLC8A1, hsa_circ_0077837, hsa_circ_0004826, and circACVR2A are among downregulated circRNAs in bladder cancer. Numerous circRNAs have diagnostic or prognostic value in bladder cancer. In this review, we aim to outline the latest findings about the role of circRNAs in bladder cancer and introduce circRNAs for further investigations as therapeutic targets. Frontiers Media S.A. 2022-02-28 /pmc/articles/PMC8918517/ /pubmed/35296022 http://dx.doi.org/10.3389/fonc.2022.801842 Text en Copyright © 2022 Ghafouri-Fard, Najafi, Hussen, Basiri, Hidayat, Taheri and Rashnoo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ghafouri-Fard, Soudeh
Najafi, Sajad
Hussen, Bashdar Mahmud
Basiri, Abbas
Hidayat, Hazha Jamal
Taheri, Mohammad
Rashnoo, Fariborz
The Role of Circular RNAs in the Carcinogenesis of Bladder Cancer
title The Role of Circular RNAs in the Carcinogenesis of Bladder Cancer
title_full The Role of Circular RNAs in the Carcinogenesis of Bladder Cancer
title_fullStr The Role of Circular RNAs in the Carcinogenesis of Bladder Cancer
title_full_unstemmed The Role of Circular RNAs in the Carcinogenesis of Bladder Cancer
title_short The Role of Circular RNAs in the Carcinogenesis of Bladder Cancer
title_sort role of circular rnas in the carcinogenesis of bladder cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918517/
https://www.ncbi.nlm.nih.gov/pubmed/35296022
http://dx.doi.org/10.3389/fonc.2022.801842
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