DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation

DNMT3A mutations play a prominent role in clonal hematopoiesis and myeloid neoplasms with arginine (R)882 as a hotspot, however the clinical implications of R882 vs. non-R882 mutations in myeloid neoplasms like myelodysplastic syndrome (MDS) is unclear. By data mining with publicly accessible cancer...

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Detalles Bibliográficos
Autores principales: Jawad, Majd, Afkhami, Michelle, Ding, Yi, Zhang, Xiaohui, Li, Peng, Young, Kim, Xu, Mina Luqing, Cui, Wei, Zhao, Yiqing, Halene, Stephanie, Al-Kali, Aref, Viswanatha, David, Chen, Dong, He, Rong, Zheng, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918526/
https://www.ncbi.nlm.nih.gov/pubmed/35296003
http://dx.doi.org/10.3389/fonc.2022.849376

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