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Sulcal Cavitation in Linear Head Acceleration: Possible Correlation With Chronic Traumatic Encephalopathy

Traumatic Brain Injury (TBI) is a significant public health and financial concern that is affecting tens of thousands of people in the United States annually. There were over a million hospital visits related to TBI in 2017. Along with immediate and short-term morbidity from TBI, chronic traumatic e...

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Autores principales: Kerwin, Joseph, Yücesoy, Atacan, Vidhate, Suhas, Dávila-Montero, Bianca M., Van Orman, Jacob L., Pence, Thomas J., Tartis, Michaelann, Mejía-Alvarez, Ricardo, Willis, Adam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918564/
https://www.ncbi.nlm.nih.gov/pubmed/35295830
http://dx.doi.org/10.3389/fneur.2022.832370
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author Kerwin, Joseph
Yücesoy, Atacan
Vidhate, Suhas
Dávila-Montero, Bianca M.
Van Orman, Jacob L.
Pence, Thomas J.
Tartis, Michaelann
Mejía-Alvarez, Ricardo
Willis, Adam M.
author_facet Kerwin, Joseph
Yücesoy, Atacan
Vidhate, Suhas
Dávila-Montero, Bianca M.
Van Orman, Jacob L.
Pence, Thomas J.
Tartis, Michaelann
Mejía-Alvarez, Ricardo
Willis, Adam M.
author_sort Kerwin, Joseph
collection PubMed
description Traumatic Brain Injury (TBI) is a significant public health and financial concern that is affecting tens of thousands of people in the United States annually. There were over a million hospital visits related to TBI in 2017. Along with immediate and short-term morbidity from TBI, chronic traumatic encephalopathy (CTE) can have life-altering, chronic morbidity, yet the direct linkage of how head impacts lead to this pathology remains unknown. A possible clue is that chronic traumatic encephalopathy appears to initiate in the depths of the sulci. The purpose of this study was to isolate the injury mechanism/s associated with blunt force impact events. To this end, drop tower experiments were performed on a human head phantom. Our phantom was fabricated into a three-dimensional extruded ellipsoid geometry made out of Polyacrylamide gelatin that incorporated gyri-sulci interaction. The phantom was assembled into a polylactic acid 3D-printed skull, surrounded with deionized water, and enclosed between two optical windows. The phantom received repetitive low-force impacts on the order of magnitude of an average boxing punch. Intracranial pressure profiles were recorded in conjunction with high-speed imaging, 25 k frames-per-second. Cavitation was observed in all trials. Cavitation is the spontaneous formation of vapor bubbles in the liquid phase resulting from a pressure drop that reaches the vapor pressure of the liquid. The observed cavitation was predominately located in the contrecoup during negative pressure phases of local intracranial pressure. To further investigate the cavitation interaction with the brain tissue phantom, a 2D plane strain computational model was built to simulate the deformation of gyrated tissue as a result from the initiation of cavitation bubbles seen in the phantom experiments. These computational experiments demonstrated a focusing of strain at the depths of the sulci from bubble expansion. Our results add further evidence that mechanical interactions could contribute to the development of chronic traumatic encephalopathy and also that fluid cavitation may play a role in this interaction.
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spelling pubmed-89185642022-03-15 Sulcal Cavitation in Linear Head Acceleration: Possible Correlation With Chronic Traumatic Encephalopathy Kerwin, Joseph Yücesoy, Atacan Vidhate, Suhas Dávila-Montero, Bianca M. Van Orman, Jacob L. Pence, Thomas J. Tartis, Michaelann Mejía-Alvarez, Ricardo Willis, Adam M. Front Neurol Neurology Traumatic Brain Injury (TBI) is a significant public health and financial concern that is affecting tens of thousands of people in the United States annually. There were over a million hospital visits related to TBI in 2017. Along with immediate and short-term morbidity from TBI, chronic traumatic encephalopathy (CTE) can have life-altering, chronic morbidity, yet the direct linkage of how head impacts lead to this pathology remains unknown. A possible clue is that chronic traumatic encephalopathy appears to initiate in the depths of the sulci. The purpose of this study was to isolate the injury mechanism/s associated with blunt force impact events. To this end, drop tower experiments were performed on a human head phantom. Our phantom was fabricated into a three-dimensional extruded ellipsoid geometry made out of Polyacrylamide gelatin that incorporated gyri-sulci interaction. The phantom was assembled into a polylactic acid 3D-printed skull, surrounded with deionized water, and enclosed between two optical windows. The phantom received repetitive low-force impacts on the order of magnitude of an average boxing punch. Intracranial pressure profiles were recorded in conjunction with high-speed imaging, 25 k frames-per-second. Cavitation was observed in all trials. Cavitation is the spontaneous formation of vapor bubbles in the liquid phase resulting from a pressure drop that reaches the vapor pressure of the liquid. The observed cavitation was predominately located in the contrecoup during negative pressure phases of local intracranial pressure. To further investigate the cavitation interaction with the brain tissue phantom, a 2D plane strain computational model was built to simulate the deformation of gyrated tissue as a result from the initiation of cavitation bubbles seen in the phantom experiments. These computational experiments demonstrated a focusing of strain at the depths of the sulci from bubble expansion. Our results add further evidence that mechanical interactions could contribute to the development of chronic traumatic encephalopathy and also that fluid cavitation may play a role in this interaction. Frontiers Media S.A. 2022-02-28 /pmc/articles/PMC8918564/ /pubmed/35295830 http://dx.doi.org/10.3389/fneur.2022.832370 Text en Copyright © 2022 Kerwin, Yücesoy, Vidhate, Dávila-Montero, Van Orman, Pence, Tartis, Mejía-Alvarez and Willis. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Kerwin, Joseph
Yücesoy, Atacan
Vidhate, Suhas
Dávila-Montero, Bianca M.
Van Orman, Jacob L.
Pence, Thomas J.
Tartis, Michaelann
Mejía-Alvarez, Ricardo
Willis, Adam M.
Sulcal Cavitation in Linear Head Acceleration: Possible Correlation With Chronic Traumatic Encephalopathy
title Sulcal Cavitation in Linear Head Acceleration: Possible Correlation With Chronic Traumatic Encephalopathy
title_full Sulcal Cavitation in Linear Head Acceleration: Possible Correlation With Chronic Traumatic Encephalopathy
title_fullStr Sulcal Cavitation in Linear Head Acceleration: Possible Correlation With Chronic Traumatic Encephalopathy
title_full_unstemmed Sulcal Cavitation in Linear Head Acceleration: Possible Correlation With Chronic Traumatic Encephalopathy
title_short Sulcal Cavitation in Linear Head Acceleration: Possible Correlation With Chronic Traumatic Encephalopathy
title_sort sulcal cavitation in linear head acceleration: possible correlation with chronic traumatic encephalopathy
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918564/
https://www.ncbi.nlm.nih.gov/pubmed/35295830
http://dx.doi.org/10.3389/fneur.2022.832370
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