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COVID-19-Associated Candidiasis: Possible Patho-Mechanism, Predisposing Factors, and Prevention Strategies

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is threatening public health. A large number of affected people need to be hospitalized. Immunocompromised patients and ICU-admitted patients are predisposed to further bacterial and fung...

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Autores principales: Ahmed, Nafisa, Mahmood, Maiesha Samiha, Ullah, Md. Asad, Araf, Yusha, Rahaman, Tanjim Ishraq, Moin, Abu Tayab, Hosen, Mohammad Jakir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918595/
https://www.ncbi.nlm.nih.gov/pubmed/35287179
http://dx.doi.org/10.1007/s00284-022-02824-6
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author Ahmed, Nafisa
Mahmood, Maiesha Samiha
Ullah, Md. Asad
Araf, Yusha
Rahaman, Tanjim Ishraq
Moin, Abu Tayab
Hosen, Mohammad Jakir
author_facet Ahmed, Nafisa
Mahmood, Maiesha Samiha
Ullah, Md. Asad
Araf, Yusha
Rahaman, Tanjim Ishraq
Moin, Abu Tayab
Hosen, Mohammad Jakir
author_sort Ahmed, Nafisa
collection PubMed
description The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is threatening public health. A large number of affected people need to be hospitalized. Immunocompromised patients and ICU-admitted patients are predisposed to further bacterial and fungal infections, making patient outcomes more critical. Among them, COVID-19-associated candidiasis is becoming more widely recognized as a part of severe COVID-19 sequelae. While the molecular pathophysiology is not fully understood, some factors, including a compromised immune system, iron and zinc deficiencies, and nosocomial and iatrogenic transmissions, predispose COVID-19 patients to candidiasis. In this review, we discuss the existing knowledge of the virulence characteristics of Candida spp. and summarize the key concepts in the possible molecular pathogenesis. We analyze the predisposing factors that make COVID-19 patients more susceptible to candidiasis and the preventive measures which will provide valuable insights to guide the effective prevention of candidiasis in COVID-19 patients.
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spelling pubmed-89185952022-03-14 COVID-19-Associated Candidiasis: Possible Patho-Mechanism, Predisposing Factors, and Prevention Strategies Ahmed, Nafisa Mahmood, Maiesha Samiha Ullah, Md. Asad Araf, Yusha Rahaman, Tanjim Ishraq Moin, Abu Tayab Hosen, Mohammad Jakir Curr Microbiol Review Article The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is threatening public health. A large number of affected people need to be hospitalized. Immunocompromised patients and ICU-admitted patients are predisposed to further bacterial and fungal infections, making patient outcomes more critical. Among them, COVID-19-associated candidiasis is becoming more widely recognized as a part of severe COVID-19 sequelae. While the molecular pathophysiology is not fully understood, some factors, including a compromised immune system, iron and zinc deficiencies, and nosocomial and iatrogenic transmissions, predispose COVID-19 patients to candidiasis. In this review, we discuss the existing knowledge of the virulence characteristics of Candida spp. and summarize the key concepts in the possible molecular pathogenesis. We analyze the predisposing factors that make COVID-19 patients more susceptible to candidiasis and the preventive measures which will provide valuable insights to guide the effective prevention of candidiasis in COVID-19 patients. Springer US 2022-03-14 2022 /pmc/articles/PMC8918595/ /pubmed/35287179 http://dx.doi.org/10.1007/s00284-022-02824-6 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Ahmed, Nafisa
Mahmood, Maiesha Samiha
Ullah, Md. Asad
Araf, Yusha
Rahaman, Tanjim Ishraq
Moin, Abu Tayab
Hosen, Mohammad Jakir
COVID-19-Associated Candidiasis: Possible Patho-Mechanism, Predisposing Factors, and Prevention Strategies
title COVID-19-Associated Candidiasis: Possible Patho-Mechanism, Predisposing Factors, and Prevention Strategies
title_full COVID-19-Associated Candidiasis: Possible Patho-Mechanism, Predisposing Factors, and Prevention Strategies
title_fullStr COVID-19-Associated Candidiasis: Possible Patho-Mechanism, Predisposing Factors, and Prevention Strategies
title_full_unstemmed COVID-19-Associated Candidiasis: Possible Patho-Mechanism, Predisposing Factors, and Prevention Strategies
title_short COVID-19-Associated Candidiasis: Possible Patho-Mechanism, Predisposing Factors, and Prevention Strategies
title_sort covid-19-associated candidiasis: possible patho-mechanism, predisposing factors, and prevention strategies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918595/
https://www.ncbi.nlm.nih.gov/pubmed/35287179
http://dx.doi.org/10.1007/s00284-022-02824-6
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