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Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells

Vulvovaginal candidiasis (VVC) is an inflammatory disease of the vagina mainly caused by Candida albicans (C. albicans), which affects around three-quarters of all women during their reproductive age. Although some antifungal drugs such as azoles have been applied clinically for many years, their th...

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Autores principales: Zhao, Ting, Zhang, Kang, Shi, Gaoxiang, Ma, Kelong, Wang, Benfan, Shao, Jing, Wang, Tianming, Wang, Changzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918845/
https://www.ncbi.nlm.nih.gov/pubmed/35295335
http://dx.doi.org/10.3389/fphar.2022.814883
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author Zhao, Ting
Zhang, Kang
Shi, Gaoxiang
Ma, Kelong
Wang, Benfan
Shao, Jing
Wang, Tianming
Wang, Changzhong
author_facet Zhao, Ting
Zhang, Kang
Shi, Gaoxiang
Ma, Kelong
Wang, Benfan
Shao, Jing
Wang, Tianming
Wang, Changzhong
author_sort Zhao, Ting
collection PubMed
description Vulvovaginal candidiasis (VVC) is an inflammatory disease of the vagina mainly caused by Candida albicans (C. albicans), which affects around three-quarters of all women during their reproductive age. Although some antifungal drugs such as azoles have been applied clinically for many years, their therapeutic value is very limited due to the emergence of drug-resistant strains. Previous studies have shown that the adhesion of C. albicans to vaginal epithelial cells is essential for the pathogenesis of VVC. Therefore, preventing the adhesion of C. albicans to vaginal epithelial cells may be one of the most effective strategies for the treatment of VVC. Berberine (BBR) is a biologically active herbal alkaloid that was used to treat VVC. However, so far, its mechanism has remained unclear. This study shows BBR significantly inhibits the adhesion of C. albicans to vaginal epithelial cells by reducing the expressions of ICAM-1, mucin1, and mucin4 in vaginal epithelial cells, which play the most important role in modulating the adhesion of C. albicans to host cells, and balancing IL-2 and IL-4 expressions, which play a key effect on regulating the inflammatory response caused by C. albicans infection. Hence, our findings demonstrate that BBR may be a potential therapeutic agent for VVC by interfering with the adhesion of C. albicans to vaginal epithelial cells and represents a new pathway for developing antifungal therapies agents from natural herbs.
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spelling pubmed-89188452022-03-15 Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells Zhao, Ting Zhang, Kang Shi, Gaoxiang Ma, Kelong Wang, Benfan Shao, Jing Wang, Tianming Wang, Changzhong Front Pharmacol Pharmacology Vulvovaginal candidiasis (VVC) is an inflammatory disease of the vagina mainly caused by Candida albicans (C. albicans), which affects around three-quarters of all women during their reproductive age. Although some antifungal drugs such as azoles have been applied clinically for many years, their therapeutic value is very limited due to the emergence of drug-resistant strains. Previous studies have shown that the adhesion of C. albicans to vaginal epithelial cells is essential for the pathogenesis of VVC. Therefore, preventing the adhesion of C. albicans to vaginal epithelial cells may be one of the most effective strategies for the treatment of VVC. Berberine (BBR) is a biologically active herbal alkaloid that was used to treat VVC. However, so far, its mechanism has remained unclear. This study shows BBR significantly inhibits the adhesion of C. albicans to vaginal epithelial cells by reducing the expressions of ICAM-1, mucin1, and mucin4 in vaginal epithelial cells, which play the most important role in modulating the adhesion of C. albicans to host cells, and balancing IL-2 and IL-4 expressions, which play a key effect on regulating the inflammatory response caused by C. albicans infection. Hence, our findings demonstrate that BBR may be a potential therapeutic agent for VVC by interfering with the adhesion of C. albicans to vaginal epithelial cells and represents a new pathway for developing antifungal therapies agents from natural herbs. Frontiers Media S.A. 2022-02-28 /pmc/articles/PMC8918845/ /pubmed/35295335 http://dx.doi.org/10.3389/fphar.2022.814883 Text en Copyright © 2022 Zhao, Zhang, Shi, Ma, Wang, Shao, Wang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhao, Ting
Zhang, Kang
Shi, Gaoxiang
Ma, Kelong
Wang, Benfan
Shao, Jing
Wang, Tianming
Wang, Changzhong
Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells
title Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells
title_full Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells
title_fullStr Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells
title_full_unstemmed Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells
title_short Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells
title_sort berberine inhibits the adhesion of candida albicans to vaginal epithelial cells
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918845/
https://www.ncbi.nlm.nih.gov/pubmed/35295335
http://dx.doi.org/10.3389/fphar.2022.814883
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