Cargando…

Polymyositis Presenting With Nontraumatic Rhabdomyolysis and Dysphagia: A Case Report

Idiopathic inflammatory myopathies (IIMs) are a rare, heterogeneous group of diseases with a characteristic clinical presentation consisting of muscle inflammation and weakness. They often present with accompanying extra-muscular findings, most notably in the skin, lungs, and joints. Inflammatory my...

Descripción completa

Detalles Bibliográficos
Autores principales: Aldrete, Jonathan, Peterson, Christopher J., Tarbox, James A., Pixley, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918959/
https://www.ncbi.nlm.nih.gov/pubmed/35264047
http://dx.doi.org/10.1177/23247096221074589
_version_ 1784668847032238080
author Aldrete, Jonathan
Peterson, Christopher J.
Tarbox, James A.
Pixley, John S.
author_facet Aldrete, Jonathan
Peterson, Christopher J.
Tarbox, James A.
Pixley, John S.
author_sort Aldrete, Jonathan
collection PubMed
description Idiopathic inflammatory myopathies (IIMs) are a rare, heterogeneous group of diseases with a characteristic clinical presentation consisting of muscle inflammation and weakness. They often present with accompanying extra-muscular findings, most notably in the skin, lungs, and joints. Inflammatory myopathies are also identified by their characteristic laboratory abnormalities, including a 10- to 50-fold increase in creatinine kinase, elevated liver enzymes, and characteristic electromyography and magnetic resonance imaging findings. Distinct autoimmune markers and clinical phenotypes have advanced our understanding of IIMs and have led to the recognition of 5 distinct entities, each with its unique pathophysiology, autoimmune markers, and clinical features. While autoimmune panels and muscle biopsies help clinicians distinguish one entity from the other, their sensitivity and specificity vary. Of the various inflammatory myopathies, polymyositis remains the most elusive. Often, the diagnosis is ultimately made by combining clinical findings and laboratory data. As our case report illustrates, clinicians must use this constellation of data to initiate treatment for suspected polymyositis despite negative autoimmune panels and negative muscle biopsy.
format Online
Article
Text
id pubmed-8918959
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-89189592022-03-15 Polymyositis Presenting With Nontraumatic Rhabdomyolysis and Dysphagia: A Case Report Aldrete, Jonathan Peterson, Christopher J. Tarbox, James A. Pixley, John S. J Investig Med High Impact Case Rep Case Report Idiopathic inflammatory myopathies (IIMs) are a rare, heterogeneous group of diseases with a characteristic clinical presentation consisting of muscle inflammation and weakness. They often present with accompanying extra-muscular findings, most notably in the skin, lungs, and joints. Inflammatory myopathies are also identified by their characteristic laboratory abnormalities, including a 10- to 50-fold increase in creatinine kinase, elevated liver enzymes, and characteristic electromyography and magnetic resonance imaging findings. Distinct autoimmune markers and clinical phenotypes have advanced our understanding of IIMs and have led to the recognition of 5 distinct entities, each with its unique pathophysiology, autoimmune markers, and clinical features. While autoimmune panels and muscle biopsies help clinicians distinguish one entity from the other, their sensitivity and specificity vary. Of the various inflammatory myopathies, polymyositis remains the most elusive. Often, the diagnosis is ultimately made by combining clinical findings and laboratory data. As our case report illustrates, clinicians must use this constellation of data to initiate treatment for suspected polymyositis despite negative autoimmune panels and negative muscle biopsy. SAGE Publications 2022-03-10 /pmc/articles/PMC8918959/ /pubmed/35264047 http://dx.doi.org/10.1177/23247096221074589 Text en © 2022 American Federation for Medical Research https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Aldrete, Jonathan
Peterson, Christopher J.
Tarbox, James A.
Pixley, John S.
Polymyositis Presenting With Nontraumatic Rhabdomyolysis and Dysphagia: A Case Report
title Polymyositis Presenting With Nontraumatic Rhabdomyolysis and Dysphagia: A Case Report
title_full Polymyositis Presenting With Nontraumatic Rhabdomyolysis and Dysphagia: A Case Report
title_fullStr Polymyositis Presenting With Nontraumatic Rhabdomyolysis and Dysphagia: A Case Report
title_full_unstemmed Polymyositis Presenting With Nontraumatic Rhabdomyolysis and Dysphagia: A Case Report
title_short Polymyositis Presenting With Nontraumatic Rhabdomyolysis and Dysphagia: A Case Report
title_sort polymyositis presenting with nontraumatic rhabdomyolysis and dysphagia: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918959/
https://www.ncbi.nlm.nih.gov/pubmed/35264047
http://dx.doi.org/10.1177/23247096221074589
work_keys_str_mv AT aldretejonathan polymyositispresentingwithnontraumaticrhabdomyolysisanddysphagiaacasereport
AT petersonchristopherj polymyositispresentingwithnontraumaticrhabdomyolysisanddysphagiaacasereport
AT tarboxjamesa polymyositispresentingwithnontraumaticrhabdomyolysisanddysphagiaacasereport
AT pixleyjohns polymyositispresentingwithnontraumaticrhabdomyolysisanddysphagiaacasereport