Design, synthesis, biochemical evaluation, radiolabeling and in vivo imaging with high affinity class-IIa histone deacetylase inhibitor for molecular imaging and targeted therapy

Herein, we describe the design, synthesis and deciphering of the key characteristics of the structure activity relationship (SAR) of trifluoromethyloxadiazole (TFMO) bearing class-IIa HDAC inhibitors. Our medicinal chemistry campaign of 23 compounds identified compound 1 as a highly potent inhibitor...

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Detalles Bibliográficos
Autores principales: Turkman, Nashaat, Liu, Daxing, Pirola, Isabella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919062/
https://www.ncbi.nlm.nih.gov/pubmed/34875522
http://dx.doi.org/10.1016/j.ejmech.2021.114011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919062/
https://www.ncbi.nlm.nih.gov/pubmed/34875522
http://dx.doi.org/10.1016/j.ejmech.2021.114011

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