Cargando…

Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy

Genome sequencing can be used to detect DNA repair failures in tumors and learn about underlying mechanisms. Here, we synthesize findings from genomic studies that examined deficiencies of the DNA mismatch repair (MMR) pathway. The impairment of MMR results in genome-wide hypermutation and in the ‘m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mas-Ponte, David, McCullough, Marcel, Supek, Fran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2022
Materias:	Cancer
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919091/ https://www.ncbi.nlm.nih.gov/pubmed/35274136 http://dx.doi.org/10.1042/CS20210682

Ejemplares similares

DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers
por: Mas-Ponte, David, et al.
Publicado: (2020)

Differential DNA mismatch repair underlies mutation rate variation across the human genome
por: Supek, Fran, et al.
Publicado: (2015)

Prevalence and spectrum of DNA mismatch repair gene variation in the general Chinese population
por: Zhang, Li, et al.
Publicado: (2022)

Passenger mutations accurately classify human tumors
por: Salvadores, Marina, et al.
Publicado: (2019)

Assessment of mismatch repair deficiency in ovarian cancer
por: Crosbie, Emma J, et al.
Publicado: (2021)

Mismatch repair status between primary colorectal tumor and metastatic tumor, a retrospective consistent study
por: Wang, Zheng, et al.
Publicado: (2019)

Survival of Patients with Deficient Mismatch Repair Versus Proficient Mismatch Repair Metastatic Colorectal Cancer Receiving Curative-Intent Local Treatment of Metastases in a Nationwide Cohort
por: Zwart, Koen, et al.
Publicado: (2023)

DNA mismatch repair deficiency accelerates lung neoplasm development in K-ras(LA1/+) mice: a brief report
por: Downey, Charlene M, et al.
Publicado: (2015)

Mutational spectrum of DNA damage and mismatch repair genes in prostate cancer
por: Bugoye, Fidelis Charles, et al.
Publicado: (2023)

Impact of age and mismatch repair status on survival in colorectal cancer
por: Li, Pan, et al.
Publicado: (2017)

Targeted next‐generation sequencing of 22 mismatch repair genes identifies Lynch syndrome families
por: Talseth‐Palmer, Bente A., et al.
Publicado: (2016)

Mismatch repair-signature mutations activate gene enhancers across human colorectal cancer epigenomes
por: Hung, Stevephen, et al.
Publicado: (2019)

Screening for mismatch repair deficiency in colorectal cancer: data from three academic medical centers
por: O'Kane, Grainne M., et al.
Publicado: (2017)

Tumor Frameshift Mutation Proportion Predicts Response to Immunotherapy in Mismatch Repair‐Deficient Prostate Cancer
por: Sena, Laura A., et al.
Publicado: (2020)

Advances in genetic technologies result in improved diagnosis of mismatch repair deficiency in colorectal and endometrial cancers
por: Evans, D Gareth, et al.
Publicado: (2022)

DNA Mismatch Repair and Oxidative DNA Damage: Implications for Cancer Biology and Treatment
por: Bridge, Gemma, et al.
Publicado: (2014)

Prevalence of Lynch syndrome in women with mismatch repair‐deficient ovarian cancer
por: Hodan, Rachel, et al.
Publicado: (2020)

Base excision repair and its implications to cancer therapy
por: Grundy, Gabrielle J., et al.
Publicado: (2020)

Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition
por: Roepman, Paul, et al.
Publicado: (2014)

Correction: Base excision repair and its implications to cancer therapy
Publicado: (2020)

Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells
por: Biayna, Josep, et al.
Publicado: (2021)

Evolving DNA repair synthetic lethality targets in cancer
por: Kulkarni, Sanat, et al.
Publicado: (2022)

DNA damage and repair dependencies of ionising radiation modalities
por: Melia, Emma, et al.
Publicado: (2023)

Programmed death‐ligand 1 expression in gastric cancer: correlation with mismatch repair deficiency and HER2‐negative status
por: Wang, Lei, et al.
Publicado: (2018)

BRAF Mutations Are Associated with Poor Survival Outcomes in Advanced-stage Mismatch Repair-deficient/Microsatellite High Colorectal Cancer
por: Tan, Elaine, et al.
Publicado: (2022)

Germline mismatch repair gene variants analyzed by universal sequencing in Japanese cancer patients
por: Kiyozumi, Yoshimi, et al.
Publicado: (2019)

DNA Mismatch Repair in Eukaryotes and Bacteria
por: Fukui, Kenji
Publicado: (2010)

DNA mismatch repair in the context of chromatin
por: Huang, Yaping, et al.
Publicado: (2020)

DNA mismatch repair in cancer immunotherapy
por: Guan, Junhong, et al.
Publicado: (2023)

A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer
por: Yarchoan, Mark, et al.
Publicado: (2019)

Perioperative Chemotherapy Could Not Improve the Prognosis of Gastric Cancer Patients With Mismatch Repair Deficiency: A Multicenter, Real-World Study
por: Zhao, Lulu, et al.
Publicado: (2023)

A framework for mutational signature analysis based on DNA shape parameters
por: Karolak, Aleksandra, et al.
Publicado: (2022)

Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining
por: Kefala Stavridi, Antonia, et al.
Publicado: (2020)

Sugar- and Artificially-Sweetened Beverages and Cancer Mortality in a Large U.S. Prospective Cohort
por: McCullough, Marjorie, et al.
Publicado: (2022)

Mismatch repair protein and MLH1 methylation status as predictors of response to adjuvant therapy in endometrial cancer
por: Loukovaara, Mikko, et al.
Publicado: (2021)

DNA mismatch repair gene MSH6 implicated in determining age at natural menopause
por: Perry, John R.B., et al.
Publicado: (2014)

Human DNA mismatch repair: coupling of mismatch recognition to strand-specific excision
por: Wang, Huixian, et al.
Publicado: (2007)

Regulation of DNA damage responses by mismatch repair
por: Zhitkovich, Anatoly
Publicado: (2010)

Correction to: DNA mismatch repair in the context of chromatin
por: Huang, Yaping, et al.
Publicado: (2020)

Combination of lysine‐specific demethylase 6A (KDM6A) and mismatch repair (MMR) status is a potential prognostic factor in colorectal cancer
por: Chen, Xiaying, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9jjgu3g7ea5jobasjbnrjgl8vl