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Severe and long‐lasting neuropsychiatric symptoms after mild respiratory symptoms caused by COVID‐19: A case report
BACKGROUND: Coronavirus disease 2019 (COVID‐19) is known to cause not only respiratory but also neuropsychiatric symptoms, which are assumed to be derived from a cytokine storm and its effects on the central nervous systems. Patients with COVID‐19 who develop severe respiratory symptoms are known to...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919122/ https://www.ncbi.nlm.nih.gov/pubmed/34889531 http://dx.doi.org/10.1002/npr2.12222 |
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author | Jozuka, Ryosuke Kimura, Hiroki Uematsu, Takashi Fujigaki, Hidetsugu Yamamoto, Yasuko Kobayashi, Masato Kawabata, Kazuya Koike, Haruki Inada, Toshiya Saito, Kuniaki Katsuno, Masahisa Ozaki, Norio |
author_facet | Jozuka, Ryosuke Kimura, Hiroki Uematsu, Takashi Fujigaki, Hidetsugu Yamamoto, Yasuko Kobayashi, Masato Kawabata, Kazuya Koike, Haruki Inada, Toshiya Saito, Kuniaki Katsuno, Masahisa Ozaki, Norio |
author_sort | Jozuka, Ryosuke |
collection | PubMed |
description | BACKGROUND: Coronavirus disease 2019 (COVID‐19) is known to cause not only respiratory but also neuropsychiatric symptoms, which are assumed to be derived from a cytokine storm and its effects on the central nervous systems. Patients with COVID‐19 who develop severe respiratory symptoms are known to show severe neuropsychiatric symptoms such as cerebrovascular disease and encephalopathy. However, the detailed clinical courses of patients with neuropsychiatric symptoms caused by mild or asymptomatic COVID‐19 remain poorly understood. Here, we present a case of COVID‐19 who presented with severe and prolonged neuropsychiatric symptoms subsequent to mild respiratory symptoms. CASE PRESENTATION: A 55‐year‐old female with COVID‐19 accompanied by mild respiratory symptoms showed delusion, psychomotor excitement, and poor communication ability during quarantine outside the hospital. Considering her diminished respiratory symptoms, her neuropsychiatric symptoms were initially regarded as psychogenic reactions. However, as she showed progressive disturbance of consciousness accompanied by an abnormal electroencephalogram, she was diagnosed with post‐COVID‐19 encephalopathy. Although her impaired consciousness and elevated cytokine level improved after steroid pulse therapy, several neuropsychiatric symptoms, including a loss of concentration, unsteadiness while walking, and fatigue, remained. CONCLUSIONS: This case suggests the importance of both recognizing that even apparently mild COVID‐19‐related respiratory symptoms can lead to severe and persistent neuropsychiatric symptoms, and elucidating the mechanisms, treatment, and long‐term course of COVID‐19‐related neuropsychiatric symptoms in the future. |
format | Online Article Text |
id | pubmed-8919122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89191222022-03-18 Severe and long‐lasting neuropsychiatric symptoms after mild respiratory symptoms caused by COVID‐19: A case report Jozuka, Ryosuke Kimura, Hiroki Uematsu, Takashi Fujigaki, Hidetsugu Yamamoto, Yasuko Kobayashi, Masato Kawabata, Kazuya Koike, Haruki Inada, Toshiya Saito, Kuniaki Katsuno, Masahisa Ozaki, Norio Neuropsychopharmacol Rep Case Reports BACKGROUND: Coronavirus disease 2019 (COVID‐19) is known to cause not only respiratory but also neuropsychiatric symptoms, which are assumed to be derived from a cytokine storm and its effects on the central nervous systems. Patients with COVID‐19 who develop severe respiratory symptoms are known to show severe neuropsychiatric symptoms such as cerebrovascular disease and encephalopathy. However, the detailed clinical courses of patients with neuropsychiatric symptoms caused by mild or asymptomatic COVID‐19 remain poorly understood. Here, we present a case of COVID‐19 who presented with severe and prolonged neuropsychiatric symptoms subsequent to mild respiratory symptoms. CASE PRESENTATION: A 55‐year‐old female with COVID‐19 accompanied by mild respiratory symptoms showed delusion, psychomotor excitement, and poor communication ability during quarantine outside the hospital. Considering her diminished respiratory symptoms, her neuropsychiatric symptoms were initially regarded as psychogenic reactions. However, as she showed progressive disturbance of consciousness accompanied by an abnormal electroencephalogram, she was diagnosed with post‐COVID‐19 encephalopathy. Although her impaired consciousness and elevated cytokine level improved after steroid pulse therapy, several neuropsychiatric symptoms, including a loss of concentration, unsteadiness while walking, and fatigue, remained. CONCLUSIONS: This case suggests the importance of both recognizing that even apparently mild COVID‐19‐related respiratory symptoms can lead to severe and persistent neuropsychiatric symptoms, and elucidating the mechanisms, treatment, and long‐term course of COVID‐19‐related neuropsychiatric symptoms in the future. John Wiley and Sons Inc. 2021-12-10 /pmc/articles/PMC8919122/ /pubmed/34889531 http://dx.doi.org/10.1002/npr2.12222 Text en © 2021 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Case Reports Jozuka, Ryosuke Kimura, Hiroki Uematsu, Takashi Fujigaki, Hidetsugu Yamamoto, Yasuko Kobayashi, Masato Kawabata, Kazuya Koike, Haruki Inada, Toshiya Saito, Kuniaki Katsuno, Masahisa Ozaki, Norio Severe and long‐lasting neuropsychiatric symptoms after mild respiratory symptoms caused by COVID‐19: A case report |
title | Severe and long‐lasting neuropsychiatric symptoms after mild respiratory symptoms caused by COVID‐19: A case report |
title_full | Severe and long‐lasting neuropsychiatric symptoms after mild respiratory symptoms caused by COVID‐19: A case report |
title_fullStr | Severe and long‐lasting neuropsychiatric symptoms after mild respiratory symptoms caused by COVID‐19: A case report |
title_full_unstemmed | Severe and long‐lasting neuropsychiatric symptoms after mild respiratory symptoms caused by COVID‐19: A case report |
title_short | Severe and long‐lasting neuropsychiatric symptoms after mild respiratory symptoms caused by COVID‐19: A case report |
title_sort | severe and long‐lasting neuropsychiatric symptoms after mild respiratory symptoms caused by covid‐19: a case report |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919122/ https://www.ncbi.nlm.nih.gov/pubmed/34889531 http://dx.doi.org/10.1002/npr2.12222 |
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