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Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications
Nanocarriers as drug/biomolecule delivery systems have been significantly developed during recent decades. Given the stability, reasonable delivery efficiency, and safety of nanocarriers, there are several barriers in the fulfillment of successful clinical application of these delivery systems. Thes...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919142/ https://www.ncbi.nlm.nih.gov/pubmed/35287692 http://dx.doi.org/10.1186/s12967-022-03325-7 |
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author | Amiri, Ala Bagherifar, Rafieh Ansari Dezfouli, Ehsan Kiaie, Seyed Hossein Jafari, Reza Ramezani, Reihaneh |
author_facet | Amiri, Ala Bagherifar, Rafieh Ansari Dezfouli, Ehsan Kiaie, Seyed Hossein Jafari, Reza Ramezani, Reihaneh |
author_sort | Amiri, Ala |
collection | PubMed |
description | Nanocarriers as drug/biomolecule delivery systems have been significantly developed during recent decades. Given the stability, reasonable delivery efficiency, and safety of nanocarriers, there are several barriers in the fulfillment of successful clinical application of these delivery systems. These challenges encouraged drug delivery researchers to establish innovative nanocarriers with longer circulation time, high stability, and high compatibility. Exosomes are extracellular nanometer-sized vesicles released through various cells. These vesicles serve as nanocarriers, possessing great potential to overcome some obstacles encountered in gene and drug delivery due to their natural affinity to recipient cells and the inherent capability to shuttle the genes, lipids, proteins, and RNAs between cells. So far, there has been a lot of valuable research on drug delivery by exosomes, but research on RNA delivery, especially mRNA, is very limited. Since mRNA-based vaccines and therapies have recently gained particular prominence in various diseases, it is essential to find a suitable delivery system due to the large size and destructive nature of these nucleic acids. That's why we're going to take a look at the unique features of exosomes and their isolation and loading methods, to embrace this idea that exosome-mediated mRNA-based therapies would be introduced as a very efficient strategy in disease treatment within the near future. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-8919142 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89191422022-03-14 Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications Amiri, Ala Bagherifar, Rafieh Ansari Dezfouli, Ehsan Kiaie, Seyed Hossein Jafari, Reza Ramezani, Reihaneh J Transl Med Review Nanocarriers as drug/biomolecule delivery systems have been significantly developed during recent decades. Given the stability, reasonable delivery efficiency, and safety of nanocarriers, there are several barriers in the fulfillment of successful clinical application of these delivery systems. These challenges encouraged drug delivery researchers to establish innovative nanocarriers with longer circulation time, high stability, and high compatibility. Exosomes are extracellular nanometer-sized vesicles released through various cells. These vesicles serve as nanocarriers, possessing great potential to overcome some obstacles encountered in gene and drug delivery due to their natural affinity to recipient cells and the inherent capability to shuttle the genes, lipids, proteins, and RNAs between cells. So far, there has been a lot of valuable research on drug delivery by exosomes, but research on RNA delivery, especially mRNA, is very limited. Since mRNA-based vaccines and therapies have recently gained particular prominence in various diseases, it is essential to find a suitable delivery system due to the large size and destructive nature of these nucleic acids. That's why we're going to take a look at the unique features of exosomes and their isolation and loading methods, to embrace this idea that exosome-mediated mRNA-based therapies would be introduced as a very efficient strategy in disease treatment within the near future. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2022-03-14 /pmc/articles/PMC8919142/ /pubmed/35287692 http://dx.doi.org/10.1186/s12967-022-03325-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Amiri, Ala Bagherifar, Rafieh Ansari Dezfouli, Ehsan Kiaie, Seyed Hossein Jafari, Reza Ramezani, Reihaneh Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications |
title | Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications |
title_full | Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications |
title_fullStr | Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications |
title_full_unstemmed | Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications |
title_short | Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications |
title_sort | exosomes as bio-inspired nanocarriers for rna delivery: preparation and applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919142/ https://www.ncbi.nlm.nih.gov/pubmed/35287692 http://dx.doi.org/10.1186/s12967-022-03325-7 |
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