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Thymoma-associated anti-LGI1 encephalitis and myasthenia gravis: A unique combination with autoantibodies

We report a 77-year-old woman with a thymoma, anti-LGI1antibody associated encephalitis (LGI1 encephalitis), and MG accompanied by positive anti-acetylcholine receptor antibodies (AchR Ab) and anti-titin antibodies (titin Ab). She was treated with thymomectomy followed by immunosuppressive therapy,...

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Autores principales: Satake, Akane, Nagasaka, Takamura, Kurita, Takafumi, Murata, Hiroaki, Hata, Takanori, Shinmura, Hiroyuki, Matsubara, Hirochika, Shindo, Kazumasa, Takiyama, Yoshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919234/
https://www.ncbi.nlm.nih.gov/pubmed/35295746
http://dx.doi.org/10.1016/j.ensci.2022.100395
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author Satake, Akane
Nagasaka, Takamura
Kurita, Takafumi
Murata, Hiroaki
Hata, Takanori
Shinmura, Hiroyuki
Matsubara, Hirochika
Shindo, Kazumasa
Takiyama, Yoshihisa
author_facet Satake, Akane
Nagasaka, Takamura
Kurita, Takafumi
Murata, Hiroaki
Hata, Takanori
Shinmura, Hiroyuki
Matsubara, Hirochika
Shindo, Kazumasa
Takiyama, Yoshihisa
author_sort Satake, Akane
collection PubMed
description We report a 77-year-old woman with a thymoma, anti-LGI1antibody associated encephalitis (LGI1 encephalitis), and MG accompanied by positive anti-acetylcholine receptor antibodies (AchR Ab) and anti-titin antibodies (titin Ab). She was treated with thymomectomy followed by immunosuppressive therapy, which resulted in immediate amelioration of motor weakness and gradual improvement of cognitive impairment over the next two years. LGI1 Ab were positive at two months after thymomectomy, followed by negative conversion demonstrated on 1 year examination. The AchR Ab level had gradually decreased but titin Ab was positive on re-examination after two years, although the cognition and motor impairment symptoms had been alleviated. In patients with suspected autoimmune encephalitis, the detection of several autoantibodies including LGI1 and thymomas provides useful information for making an accurate diagnosis.
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spelling pubmed-89192342022-03-15 Thymoma-associated anti-LGI1 encephalitis and myasthenia gravis: A unique combination with autoantibodies Satake, Akane Nagasaka, Takamura Kurita, Takafumi Murata, Hiroaki Hata, Takanori Shinmura, Hiroyuki Matsubara, Hirochika Shindo, Kazumasa Takiyama, Yoshihisa eNeurologicalSci Case Report We report a 77-year-old woman with a thymoma, anti-LGI1antibody associated encephalitis (LGI1 encephalitis), and MG accompanied by positive anti-acetylcholine receptor antibodies (AchR Ab) and anti-titin antibodies (titin Ab). She was treated with thymomectomy followed by immunosuppressive therapy, which resulted in immediate amelioration of motor weakness and gradual improvement of cognitive impairment over the next two years. LGI1 Ab were positive at two months after thymomectomy, followed by negative conversion demonstrated on 1 year examination. The AchR Ab level had gradually decreased but titin Ab was positive on re-examination after two years, although the cognition and motor impairment symptoms had been alleviated. In patients with suspected autoimmune encephalitis, the detection of several autoantibodies including LGI1 and thymomas provides useful information for making an accurate diagnosis. Elsevier 2022-03-07 /pmc/articles/PMC8919234/ /pubmed/35295746 http://dx.doi.org/10.1016/j.ensci.2022.100395 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Satake, Akane
Nagasaka, Takamura
Kurita, Takafumi
Murata, Hiroaki
Hata, Takanori
Shinmura, Hiroyuki
Matsubara, Hirochika
Shindo, Kazumasa
Takiyama, Yoshihisa
Thymoma-associated anti-LGI1 encephalitis and myasthenia gravis: A unique combination with autoantibodies
title Thymoma-associated anti-LGI1 encephalitis and myasthenia gravis: A unique combination with autoantibodies
title_full Thymoma-associated anti-LGI1 encephalitis and myasthenia gravis: A unique combination with autoantibodies
title_fullStr Thymoma-associated anti-LGI1 encephalitis and myasthenia gravis: A unique combination with autoantibodies
title_full_unstemmed Thymoma-associated anti-LGI1 encephalitis and myasthenia gravis: A unique combination with autoantibodies
title_short Thymoma-associated anti-LGI1 encephalitis and myasthenia gravis: A unique combination with autoantibodies
title_sort thymoma-associated anti-lgi1 encephalitis and myasthenia gravis: a unique combination with autoantibodies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919234/
https://www.ncbi.nlm.nih.gov/pubmed/35295746
http://dx.doi.org/10.1016/j.ensci.2022.100395
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