Exploratory imaging outcomes of a phase 1b/2a clinical trial of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: Structural effects and functional connectivity outcomes

INTRODUCTION: Allopregnanolone (ALLO), an endogenous neurosteroid, promoted neurogenesis and oligogenesis and restored cognitive function in animal models of Alzheimer's disease (AD). Based on these discovery research findings, we conducted a randomized‐controlled phase 1b/2a multiple ascending...

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Detalles Bibliográficos
Autores principales: Raikes, Adam C., Hernandez, Gerson D., Matthews, Dawn C., Lukic, Ana S., Law, Meng, Shi, Yonggang, Schneider, Lon S., Brinton, Roberta D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919249/
https://www.ncbi.nlm.nih.gov/pubmed/35310526
http://dx.doi.org/10.1002/trc2.12258

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