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Pharmacological evaluation of medicinal plants with antidiabetic activities in Ethiopia: A review

Diabetes mellitus is a serious, chronic disease that occurs either when the pancreas does not produce enough insulin, or when the body can't effectively use insulin. Herbal medicines have been commonly used by diabetic patients for the treatment of diabetes mellitus. To include findings from di...

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Autores principales: Kifle, Zemene Demelash, Abdelwuhab, Mohammedbrhan, Melak, Abreham Degu, Genet, G/Mariam, Meseret, Tesfaye, Adugna, Meaza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919291/
https://www.ncbi.nlm.nih.gov/pubmed/35296054
http://dx.doi.org/10.1016/j.metop.2022.100174
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author Kifle, Zemene Demelash
Abdelwuhab, Mohammedbrhan
Melak, Abreham Degu
Genet, G/Mariam
Meseret, Tesfaye
Adugna, Meaza
author_facet Kifle, Zemene Demelash
Abdelwuhab, Mohammedbrhan
Melak, Abreham Degu
Genet, G/Mariam
Meseret, Tesfaye
Adugna, Meaza
author_sort Kifle, Zemene Demelash
collection PubMed
description Diabetes mellitus is a serious, chronic disease that occurs either when the pancreas does not produce enough insulin, or when the body can't effectively use insulin. Herbal medicines have been commonly used by diabetic patients for the treatment of diabetes mellitus. To include findings from different studies, publications related to in vivo and invitro antidiabetic activities of medicinal plants in Ethiopia were searched from different databases, such as Web of Science, Google Scholar, Medline, Scopus, and PubMed, using English key terms. Different medicinal plant parts were used experimentally for antidiabetic effects in Ethiopia. Among these, leaves (69%) were the most commonly investigated medicinal plant parts followed by roots (14%) and seeds (7%). Most of the investigations were completed with hydro-methanolic extracts to obtain a higher percentage of yield. Medicinal plants such as Thymus schemperi R, Thymus vulgaris L, Hagenia abyssinica, Aloe megalacantha baker, Aloe moticola Reyonolds, Aloe pulecherrima Gilbert & sebseb, Bersama abyssinica fresen, and Rubus Erlangeri Engl have shown in vitro α-amylase inhibitory activity. However, only Hagenia abyssinica, Thymus schemperi R, and Thymus vulgaris L have exhibited α-glucosidase inhibitory activity. Likewise, only the extract of Aloe pulecherrima Gilbert & sebseb posses’ maltase and sucrose inhibitory activity. In vivo antidiabetic activity were conducted for the extract of medicinal plants such as A. remota, S. rebaudiani, T. schemperi, T. vulgaris, H. abyssinica, C. aurea, D. stramonium, A. megalacantha, A. moticola, A.integrifolia, A. pulecherrima, B. grandiflorum, B. abyssinica, P. schimperiana, M. stenopetala, C. aure, J. schimperiana, T. brownie, C. macrostachys, I. spicata, O. integrifolia, C. abyssinica, R. Erlangeri, L. culinaris, A. camperi, A. polystachyus, A. ilicifalius, C. tomentosa, and C. Edulis. This review gives collective evidence on the potential antidiabetic activities of medicinal plants in Ethiopia. Moreover, further studies are recommended to substantiate the use of these medicinal plants as an antidiabetic agent.
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spelling pubmed-89192912022-03-15 Pharmacological evaluation of medicinal plants with antidiabetic activities in Ethiopia: A review Kifle, Zemene Demelash Abdelwuhab, Mohammedbrhan Melak, Abreham Degu Genet, G/Mariam Meseret, Tesfaye Adugna, Meaza Metabol Open Review Diabetes mellitus is a serious, chronic disease that occurs either when the pancreas does not produce enough insulin, or when the body can't effectively use insulin. Herbal medicines have been commonly used by diabetic patients for the treatment of diabetes mellitus. To include findings from different studies, publications related to in vivo and invitro antidiabetic activities of medicinal plants in Ethiopia were searched from different databases, such as Web of Science, Google Scholar, Medline, Scopus, and PubMed, using English key terms. Different medicinal plant parts were used experimentally for antidiabetic effects in Ethiopia. Among these, leaves (69%) were the most commonly investigated medicinal plant parts followed by roots (14%) and seeds (7%). Most of the investigations were completed with hydro-methanolic extracts to obtain a higher percentage of yield. Medicinal plants such as Thymus schemperi R, Thymus vulgaris L, Hagenia abyssinica, Aloe megalacantha baker, Aloe moticola Reyonolds, Aloe pulecherrima Gilbert & sebseb, Bersama abyssinica fresen, and Rubus Erlangeri Engl have shown in vitro α-amylase inhibitory activity. However, only Hagenia abyssinica, Thymus schemperi R, and Thymus vulgaris L have exhibited α-glucosidase inhibitory activity. Likewise, only the extract of Aloe pulecherrima Gilbert & sebseb posses’ maltase and sucrose inhibitory activity. In vivo antidiabetic activity were conducted for the extract of medicinal plants such as A. remota, S. rebaudiani, T. schemperi, T. vulgaris, H. abyssinica, C. aurea, D. stramonium, A. megalacantha, A. moticola, A.integrifolia, A. pulecherrima, B. grandiflorum, B. abyssinica, P. schimperiana, M. stenopetala, C. aure, J. schimperiana, T. brownie, C. macrostachys, I. spicata, O. integrifolia, C. abyssinica, R. Erlangeri, L. culinaris, A. camperi, A. polystachyus, A. ilicifalius, C. tomentosa, and C. Edulis. This review gives collective evidence on the potential antidiabetic activities of medicinal plants in Ethiopia. Moreover, further studies are recommended to substantiate the use of these medicinal plants as an antidiabetic agent. Elsevier 2022-03-10 /pmc/articles/PMC8919291/ /pubmed/35296054 http://dx.doi.org/10.1016/j.metop.2022.100174 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Kifle, Zemene Demelash
Abdelwuhab, Mohammedbrhan
Melak, Abreham Degu
Genet, G/Mariam
Meseret, Tesfaye
Adugna, Meaza
Pharmacological evaluation of medicinal plants with antidiabetic activities in Ethiopia: A review
title Pharmacological evaluation of medicinal plants with antidiabetic activities in Ethiopia: A review
title_full Pharmacological evaluation of medicinal plants with antidiabetic activities in Ethiopia: A review
title_fullStr Pharmacological evaluation of medicinal plants with antidiabetic activities in Ethiopia: A review
title_full_unstemmed Pharmacological evaluation of medicinal plants with antidiabetic activities in Ethiopia: A review
title_short Pharmacological evaluation of medicinal plants with antidiabetic activities in Ethiopia: A review
title_sort pharmacological evaluation of medicinal plants with antidiabetic activities in ethiopia: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919291/
https://www.ncbi.nlm.nih.gov/pubmed/35296054
http://dx.doi.org/10.1016/j.metop.2022.100174
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