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The Effect of COVID-19 Pandemic on Patients with Primary Immunodeficiency: A Cohort Study
Both adaptive and innate immune responses are essential for an effective defense against the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection. We aimed to investigate the effect of the coronavirus disease 2019 (COVID-19) pandemic on patients with primary immunodeficiency (PID)....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shiraz University of Medical Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919309/ https://www.ncbi.nlm.nih.gov/pubmed/35291437 http://dx.doi.org/10.30476/IJMS.2022.92862.2415 |
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author | Babaei, Maryam Kanannejad, Zahra Sepahi, Najmeh Alyasin, Soheila |
author_facet | Babaei, Maryam Kanannejad, Zahra Sepahi, Najmeh Alyasin, Soheila |
author_sort | Babaei, Maryam |
collection | PubMed |
description | Both adaptive and innate immune responses are essential for an effective defense against the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection. We aimed to investigate the effect of the coronavirus disease 2019 (COVID-19) pandemic on patients with primary immunodeficiency (PID). This study was performed on patients who were diagnosed with PID by immunologist specialists and referred to Imam Reza Clinic of Asthma and Allergy, affiliated with Shiraz University of Medical Sciences, (Shiraz, Iran) for regular check-ups. The patients were enrolled in this cohort study and followed for any sign of COVID-19 from March 2020 to May 2021. COVID-19 infection was confirmed using a real-time polymerase chain reaction (RT-PCR) assay of nasal and pharyngeal swabs. Among the 90 PID patients under study, nine patients (10%) were diagnosed positive for COVID-19 infection. Five out of these nine patients belonged to the combined immunodeficiency (CID) category, while four patients were categorized as having primary antibody deficiencies (PADs). Eight patients with COVID-19 were required to be admitted to the hospital, and three patients died after hospitalization due to COVID-19 infection. It seems that patients with CID are at a higher risk of mortality, due to COVID-19 infection, that other types of PID. |
format | Online Article Text |
id | pubmed-8919309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Shiraz University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-89193092022-03-14 The Effect of COVID-19 Pandemic on Patients with Primary Immunodeficiency: A Cohort Study Babaei, Maryam Kanannejad, Zahra Sepahi, Najmeh Alyasin, Soheila Iran J Med Sci Brief Report Both adaptive and innate immune responses are essential for an effective defense against the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection. We aimed to investigate the effect of the coronavirus disease 2019 (COVID-19) pandemic on patients with primary immunodeficiency (PID). This study was performed on patients who were diagnosed with PID by immunologist specialists and referred to Imam Reza Clinic of Asthma and Allergy, affiliated with Shiraz University of Medical Sciences, (Shiraz, Iran) for regular check-ups. The patients were enrolled in this cohort study and followed for any sign of COVID-19 from March 2020 to May 2021. COVID-19 infection was confirmed using a real-time polymerase chain reaction (RT-PCR) assay of nasal and pharyngeal swabs. Among the 90 PID patients under study, nine patients (10%) were diagnosed positive for COVID-19 infection. Five out of these nine patients belonged to the combined immunodeficiency (CID) category, while four patients were categorized as having primary antibody deficiencies (PADs). Eight patients with COVID-19 were required to be admitted to the hospital, and three patients died after hospitalization due to COVID-19 infection. It seems that patients with CID are at a higher risk of mortality, due to COVID-19 infection, that other types of PID. Shiraz University of Medical Sciences 2022-03 /pmc/articles/PMC8919309/ /pubmed/35291437 http://dx.doi.org/10.30476/IJMS.2022.92862.2415 Text en Copyright: © Iranian Journal of Medical Sciences https://creativecommons.org/licenses/by-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report Babaei, Maryam Kanannejad, Zahra Sepahi, Najmeh Alyasin, Soheila The Effect of COVID-19 Pandemic on Patients with Primary Immunodeficiency: A Cohort Study |
title | The Effect of COVID-19 Pandemic on Patients with Primary Immunodeficiency: A Cohort Study |
title_full | The Effect of COVID-19 Pandemic on Patients with Primary Immunodeficiency: A Cohort Study |
title_fullStr | The Effect of COVID-19 Pandemic on Patients with Primary Immunodeficiency: A Cohort Study |
title_full_unstemmed | The Effect of COVID-19 Pandemic on Patients with Primary Immunodeficiency: A Cohort Study |
title_short | The Effect of COVID-19 Pandemic on Patients with Primary Immunodeficiency: A Cohort Study |
title_sort | effect of covid-19 pandemic on patients with primary immunodeficiency: a cohort study |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919309/ https://www.ncbi.nlm.nih.gov/pubmed/35291437 http://dx.doi.org/10.30476/IJMS.2022.92862.2415 |
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