Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor Agonist

[Image: see text] TAK-925, a potent, selective, and brain-penetrant orexin 2 receptor (OX2R) agonist, [methyl (2R,3S)-3-((methylsulfonyl)amino)-2-(((cis-4-phenylcyclohexyl)oxy)methyl)piperidine-1-carboxylate, 16], was identified through the optimization of compound 2, which was discovered by a high...

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Detalles Bibliográficos
Autores principales: Fujimoto, Tatsuhiko, Rikimaru, Kentaro, Fukuda, Koichiro, Sugimoto, Hiromichi, Masuda, Kei, Ohyabu, Norio, Banno, Yoshihiro, Tokunaga, Norihito, Kawamoto, Tetsuji, Tomata, Yoshihide, Kumagai, Yasumi, Iida, Motoo, Nagano, Yoichi, Yoneyama-Hirozane, Mariko, Shimizu, Yuji, Sasa, Katsunori, Ishikawa, Takashi, Yukitake, Hiroshi, Ito, Mitsuhiro, Aoyama, Kazunobu, Matsumoto, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919389/
https://www.ncbi.nlm.nih.gov/pubmed/35295087
http://dx.doi.org/10.1021/acsmedchemlett.1c00626

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