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Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study

BACKGROUND: Barley contains abundant soluble beta-glucan fibers, which have established health benefits. In addition, the health benefits conferred by the gut bacteria have attracted considerable interest. However, few studies have focused on the barley consumption and gut bacteria of the Japanese p...

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Autores principales: Matsuoka, Tsubasa, Hosomi, Koji, Park, Jonguk, Goto, Yuka, Nishimura, Mao, Maruyama, Satoko, Murakami, Haruka, Konishi, Kana, Miyachi, Motohiko, Kawashima, Hitoshi, Mizuguchi, Kenji, Kobayashi, Toshiki, Yokomichi, Hiroshi, Kunisawa, Jun, Yamagata, Zentaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919566/
https://www.ncbi.nlm.nih.gov/pubmed/35287729
http://dx.doi.org/10.1186/s40795-022-00500-3
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author Matsuoka, Tsubasa
Hosomi, Koji
Park, Jonguk
Goto, Yuka
Nishimura, Mao
Maruyama, Satoko
Murakami, Haruka
Konishi, Kana
Miyachi, Motohiko
Kawashima, Hitoshi
Mizuguchi, Kenji
Kobayashi, Toshiki
Yokomichi, Hiroshi
Kunisawa, Jun
Yamagata, Zentaro
author_facet Matsuoka, Tsubasa
Hosomi, Koji
Park, Jonguk
Goto, Yuka
Nishimura, Mao
Maruyama, Satoko
Murakami, Haruka
Konishi, Kana
Miyachi, Motohiko
Kawashima, Hitoshi
Mizuguchi, Kenji
Kobayashi, Toshiki
Yokomichi, Hiroshi
Kunisawa, Jun
Yamagata, Zentaro
author_sort Matsuoka, Tsubasa
collection PubMed
description BACKGROUND: Barley contains abundant soluble beta-glucan fibers, which have established health benefits. In addition, the health benefits conferred by the gut bacteria have attracted considerable interest. However, few studies have focused on the barley consumption and gut bacteria of the Japanese population. In this study, we aimed to identify the relationship between the barley consumption and gut bacteria composition of the Japanese population. METHODS: In total, 236 participants were recruited in Japan, and 94 participants with no complications of diabetes, hypertension, or dyslipidemia were selected for the study. We analyzed fecal samples from the participants, their medical check-up results, and responses to questionnaires about dietary habits. The participants were grouped according to their median barley consumption. Then, we assessed the relative abundance of 50 genera. Characteristic bacteria were evaluated for their relationship with barley consumption by multiple regression analysis, adjusted for disease and dietary habits, in all participants. We also analyzed the networks and clustering of the 20 selected genera. RESULTS: According to the comparison between barley groups, Bifidobacterium, Butyricicoccus, Collinsella, Ruminococcus 2, and Dialister were characteristic candidate bacterias of the group that consumed large amounts of barley (P < 0.05). The relationship between barley consumption and Bifidobacterium remained after adjusting for disease and dietary habits, and that of Butyricicoccus remained after adjusting for disease. Furthermore, network and cluster analyses revealed that barley consumption was directly correlated with Bifidobacterium and Butyricicoccus. CONCLUSIONS: Barley consumption generates changes in the intestinal bacteria of the Japanese population. We found that Bifidobacterium and Butyricicoccus abundance was positively associated with barley consumption. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40795-022-00500-3.
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spelling pubmed-89195662022-03-16 Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study Matsuoka, Tsubasa Hosomi, Koji Park, Jonguk Goto, Yuka Nishimura, Mao Maruyama, Satoko Murakami, Haruka Konishi, Kana Miyachi, Motohiko Kawashima, Hitoshi Mizuguchi, Kenji Kobayashi, Toshiki Yokomichi, Hiroshi Kunisawa, Jun Yamagata, Zentaro BMC Nutr Research BACKGROUND: Barley contains abundant soluble beta-glucan fibers, which have established health benefits. In addition, the health benefits conferred by the gut bacteria have attracted considerable interest. However, few studies have focused on the barley consumption and gut bacteria of the Japanese population. In this study, we aimed to identify the relationship between the barley consumption and gut bacteria composition of the Japanese population. METHODS: In total, 236 participants were recruited in Japan, and 94 participants with no complications of diabetes, hypertension, or dyslipidemia were selected for the study. We analyzed fecal samples from the participants, their medical check-up results, and responses to questionnaires about dietary habits. The participants were grouped according to their median barley consumption. Then, we assessed the relative abundance of 50 genera. Characteristic bacteria were evaluated for their relationship with barley consumption by multiple regression analysis, adjusted for disease and dietary habits, in all participants. We also analyzed the networks and clustering of the 20 selected genera. RESULTS: According to the comparison between barley groups, Bifidobacterium, Butyricicoccus, Collinsella, Ruminococcus 2, and Dialister were characteristic candidate bacterias of the group that consumed large amounts of barley (P < 0.05). The relationship between barley consumption and Bifidobacterium remained after adjusting for disease and dietary habits, and that of Butyricicoccus remained after adjusting for disease. Furthermore, network and cluster analyses revealed that barley consumption was directly correlated with Bifidobacterium and Butyricicoccus. CONCLUSIONS: Barley consumption generates changes in the intestinal bacteria of the Japanese population. We found that Bifidobacterium and Butyricicoccus abundance was positively associated with barley consumption. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40795-022-00500-3. BioMed Central 2022-03-14 /pmc/articles/PMC8919566/ /pubmed/35287729 http://dx.doi.org/10.1186/s40795-022-00500-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Matsuoka, Tsubasa
Hosomi, Koji
Park, Jonguk
Goto, Yuka
Nishimura, Mao
Maruyama, Satoko
Murakami, Haruka
Konishi, Kana
Miyachi, Motohiko
Kawashima, Hitoshi
Mizuguchi, Kenji
Kobayashi, Toshiki
Yokomichi, Hiroshi
Kunisawa, Jun
Yamagata, Zentaro
Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study
title Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study
title_full Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study
title_fullStr Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study
title_full_unstemmed Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study
title_short Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study
title_sort relationships between barley consumption and gut microbiome characteristics in a healthy japanese population: a cross-sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919566/
https://www.ncbi.nlm.nih.gov/pubmed/35287729
http://dx.doi.org/10.1186/s40795-022-00500-3
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