The multifaceted roles of cohesin in cancer

The cohesin complex controls faithful chromosome segregation by pairing sister chromatids after DNA replication until mitosis. In addition, it is crucial for hierarchal three-dimensional organization of the genome, transcription regulation and maintaining DNA integrity. The core complex subunits SMC...

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Autores principales: Di Nardo, Maddalena, Pallotta, Maria M., Musio, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919599/
https://www.ncbi.nlm.nih.gov/pubmed/35287703
http://dx.doi.org/10.1186/s13046-022-02321-5
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author Di Nardo, Maddalena
Pallotta, Maria M.
Musio, Antonio
author_facet Di Nardo, Maddalena
Pallotta, Maria M.
Musio, Antonio
author_sort Di Nardo, Maddalena
collection PubMed
description The cohesin complex controls faithful chromosome segregation by pairing sister chromatids after DNA replication until mitosis. In addition, it is crucial for hierarchal three-dimensional organization of the genome, transcription regulation and maintaining DNA integrity. The core complex subunits SMC1A, SMC3, STAG1/2, and RAD21 as well as its modulators, have been found to be recurrently mutated in human cancers. The mechanisms by which cohesin mutations trigger cancer development and disease progression are still poorly understood. Since cohesin is involved in a range of chromosome-related processes, the outcome of cohesin mutations in cancer is complex. Herein, we discuss recent discoveries regarding cohesin that provide new insight into its role in tumorigenesis.
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spelling pubmed-89195992022-03-16 The multifaceted roles of cohesin in cancer Di Nardo, Maddalena Pallotta, Maria M. Musio, Antonio J Exp Clin Cancer Res Review The cohesin complex controls faithful chromosome segregation by pairing sister chromatids after DNA replication until mitosis. In addition, it is crucial for hierarchal three-dimensional organization of the genome, transcription regulation and maintaining DNA integrity. The core complex subunits SMC1A, SMC3, STAG1/2, and RAD21 as well as its modulators, have been found to be recurrently mutated in human cancers. The mechanisms by which cohesin mutations trigger cancer development and disease progression are still poorly understood. Since cohesin is involved in a range of chromosome-related processes, the outcome of cohesin mutations in cancer is complex. Herein, we discuss recent discoveries regarding cohesin that provide new insight into its role in tumorigenesis. BioMed Central 2022-03-14 /pmc/articles/PMC8919599/ /pubmed/35287703 http://dx.doi.org/10.1186/s13046-022-02321-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Di Nardo, Maddalena
Pallotta, Maria M.
Musio, Antonio
The multifaceted roles of cohesin in cancer
title The multifaceted roles of cohesin in cancer
title_full The multifaceted roles of cohesin in cancer
title_fullStr The multifaceted roles of cohesin in cancer
title_full_unstemmed The multifaceted roles of cohesin in cancer
title_short The multifaceted roles of cohesin in cancer
title_sort multifaceted roles of cohesin in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919599/
https://www.ncbi.nlm.nih.gov/pubmed/35287703
http://dx.doi.org/10.1186/s13046-022-02321-5
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