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PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen

The spleen is an important site of hematopoietic stem/progenitor cell (HSPC) preconditioning and tumor-promoting myeloid cell generation in cancer, but the regulatory mechanism remains unclear. Here, we found that PKR-like endoplasmic reticulum kinase (PERK) mediated HSPC reprogramming into committe...

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Detalles Bibliográficos
Autores principales:	Liu, Mingyu, Wu, Chong, Luo, Shufeng, Hua, Qiaomin, Chen, Hai-Tian, Weng, Yulan, Xu, Junyu, Lin, Huiling, Wang, Lu, Li, Jinheng, Zhu, Lan, Guo, Zhenhong, Zhuang, Shi-Mei, Kang, Tiebang, Zheng, Limin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919616/ https://www.ncbi.nlm.nih.gov/pubmed/35266960 http://dx.doi.org/10.1084/jem.20211498

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