The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity

Missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD); however, pathways regulating LRRK2 subcellular localization, function, and turnover are not fully defined. We performed quantitative mass spectrometry–based interactome studies...

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Detalles Bibliográficos
Autores principales: Stormo, Adrienne E.D., Shavarebi, Farbod, FitzGibbon, Molly, Earley, Elizabeth M., Ahrendt, Hannah, Lum, Lotus S., Verschueren, Erik, Swaney, Danielle L., Skibinski, Gaia, Ravisankar, Abinaya, van Haren, Jeffrey, Davis, Emily J., Johnson, Jeffrey R., Von Dollen, John, Balen, Carson, Porath, Jacob, Crosio, Claudia, Mirescu, Christian, Iaccarino, Ciro, Dauer, William T., Nichols, R. Jeremy, Wittmann, Torsten, Cox, Timothy C., Finkbeiner, Steve, Krogan, Nevan J., Oakes, Scott A., Hiniker, Annie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919618/
https://www.ncbi.nlm.nih.gov/pubmed/35266954
http://dx.doi.org/10.1083/jcb.202010065

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