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Analysis of the Clinical Characteristics and Pituitary Function of Patients in Central China With Rathke’s Cleft Cysts

OBJECTIVE: A Rathke’s cleft cyst (RCC) is a common, benign, cystic disease that often leads to hypophyseal dysfunction or head symptoms. The relationship between RCCs and pituitary gland function is not clear. We therefore carried out a study to examine this relationship in greater detail. METHODS:...

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Autores principales: Zhang, Lixia, Li, Xueyuan, Li, Chong, Wang, Zhifang, Zheng, Lili, Qin, Guijun, Wang, Shoujun, Xu, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919671/
https://www.ncbi.nlm.nih.gov/pubmed/35295993
http://dx.doi.org/10.3389/fendo.2022.800135
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author Zhang, Lixia
Li, Xueyuan
Li, Chong
Wang, Zhifang
Zheng, Lili
Qin, Guijun
Wang, Shoujun
Xu, Lijun
author_facet Zhang, Lixia
Li, Xueyuan
Li, Chong
Wang, Zhifang
Zheng, Lili
Qin, Guijun
Wang, Shoujun
Xu, Lijun
author_sort Zhang, Lixia
collection PubMed
description OBJECTIVE: A Rathke’s cleft cyst (RCC) is a common, benign, cystic disease that often leads to hypophyseal dysfunction or head symptoms. The relationship between RCCs and pituitary gland function is not clear. We therefore carried out a study to examine this relationship in greater detail. METHODS: The study was a retrospective, cohort design in patients diagnosed with a RCC between January 2019 to July 2021 at the First Affiliated Hospital of Zhengzhou University, China. RESULTS: A total of 221 patients were enrolled and then divided into study cohorts according to the diameter of the RCC, clinical manifestations, and surgical treatment received. The majority of patients were symptomatic (143/221), including 83 cases of dizziness and headache, 9 of vision loss and visual field defect, and 2 of diabetes insipidus. 52 cases had abnormal pituitary function, with 8 cases interestingly showing high adrenocorticotropic-hormone (ACTH) and cortisone levels, while 8 juvenile cases had developed central precocious puberty. Patients with larger RCCs were more likely to present with headaches and dizziness, with subjects who suffered from these symptoms having high ACTH and cortisone levels. CONCLUSION: Although the size of a RCC is not an important factor influencing hypopituitary function, we consider that endocrine evaluation should be carried out in all patients with a RCC.
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spelling pubmed-89196712022-03-15 Analysis of the Clinical Characteristics and Pituitary Function of Patients in Central China With Rathke’s Cleft Cysts Zhang, Lixia Li, Xueyuan Li, Chong Wang, Zhifang Zheng, Lili Qin, Guijun Wang, Shoujun Xu, Lijun Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: A Rathke’s cleft cyst (RCC) is a common, benign, cystic disease that often leads to hypophyseal dysfunction or head symptoms. The relationship between RCCs and pituitary gland function is not clear. We therefore carried out a study to examine this relationship in greater detail. METHODS: The study was a retrospective, cohort design in patients diagnosed with a RCC between January 2019 to July 2021 at the First Affiliated Hospital of Zhengzhou University, China. RESULTS: A total of 221 patients were enrolled and then divided into study cohorts according to the diameter of the RCC, clinical manifestations, and surgical treatment received. The majority of patients were symptomatic (143/221), including 83 cases of dizziness and headache, 9 of vision loss and visual field defect, and 2 of diabetes insipidus. 52 cases had abnormal pituitary function, with 8 cases interestingly showing high adrenocorticotropic-hormone (ACTH) and cortisone levels, while 8 juvenile cases had developed central precocious puberty. Patients with larger RCCs were more likely to present with headaches and dizziness, with subjects who suffered from these symptoms having high ACTH and cortisone levels. CONCLUSION: Although the size of a RCC is not an important factor influencing hypopituitary function, we consider that endocrine evaluation should be carried out in all patients with a RCC. Frontiers Media S.A. 2022-02-28 /pmc/articles/PMC8919671/ /pubmed/35295993 http://dx.doi.org/10.3389/fendo.2022.800135 Text en Copyright © 2022 Zhang, Li, Li, Wang, Zheng, Qin, Wang and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhang, Lixia
Li, Xueyuan
Li, Chong
Wang, Zhifang
Zheng, Lili
Qin, Guijun
Wang, Shoujun
Xu, Lijun
Analysis of the Clinical Characteristics and Pituitary Function of Patients in Central China With Rathke’s Cleft Cysts
title Analysis of the Clinical Characteristics and Pituitary Function of Patients in Central China With Rathke’s Cleft Cysts
title_full Analysis of the Clinical Characteristics and Pituitary Function of Patients in Central China With Rathke’s Cleft Cysts
title_fullStr Analysis of the Clinical Characteristics and Pituitary Function of Patients in Central China With Rathke’s Cleft Cysts
title_full_unstemmed Analysis of the Clinical Characteristics and Pituitary Function of Patients in Central China With Rathke’s Cleft Cysts
title_short Analysis of the Clinical Characteristics and Pituitary Function of Patients in Central China With Rathke’s Cleft Cysts
title_sort analysis of the clinical characteristics and pituitary function of patients in central china with rathke’s cleft cysts
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919671/
https://www.ncbi.nlm.nih.gov/pubmed/35295993
http://dx.doi.org/10.3389/fendo.2022.800135
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