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Systematic illumination of druggable genes in cancer genomes

By combining 6 druggable genome resources, we identify 6,083 genes as potential druggable genes (PDGs). We characterize their expression, recurrent genomic alterations, cancer dependencies, and therapeutic potentials by integrating genome, functionome, and druggome profiles across cancers. 81.5% of...

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Detalles Bibliográficos
Autores principales:	Jiang, Junjie, Yuan, Jiao, Hu, Zhongyi, Zhang, Youyou, Zhang, Tianli, Xu, Mu, Long, Meixiao, Fan, Yi, Tanyi, Janos L., Montone, Kathleen T., Tavana, Omid, Vonderheide, Robert H., Chan, Ho Man, Hu, Xiaowen, Zhang, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919705/ https://www.ncbi.nlm.nih.gov/pubmed/35196490 http://dx.doi.org/10.1016/j.celrep.2022.110400

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